UniProt Accession

 SPY2_HUMAN; O43597; Q5T6Z7 

Genbank Protein ID

 AF039843; AL713749; AL354668; BC015745 

Genbank Nucleotide ID

 AAC04258.1; CAD28524.1; CAI14911.1; AAH15745.1 

Protein Name

 Protein sprouty homolog 2 

Protein Synonyms/Alias

 Spry-2 

Gene Name

 SPRY2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
78	PRPSTQHKHERLHGL	methylation	[1]
164	ELKPGELKPLSKEDL	ubiquitination	[2]
313	VPPRNFEKPT*****	ubiquitination	[3]

Reference

 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. 

Sequence Annotation

 DOMAIN 177 291 SPR.  

Keyword

 3D-structure; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Membrane; Microtubule; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 315 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
 GO:0043539; F:protein serine/threonine kinase activator activity; IMP:UniProtKB.
 GO:0030291; F:protein serine/threonine kinase inhibitor activity; IC:BHF-UCL.
 GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Compara.
 GO:0045165; P:cell fate commitment; IEA:Compara.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
 GO:0042472; P:inner ear morphogenesis; IEA:Compara.
 GO:0060437; P:lung growth; IEA:Compara.
 GO:0060425; P:lung morphogenesis; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Compara.
 GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IEA:Compara.
 GO:0043407; P:negative regulation of MAP kinase activity; IEA:Compara.
 GO:0051387; P:negative regulation of neurotrophin TRK receptor signaling pathway; IEA:Compara.
 GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IDA:BHF-UCL.
 GO:0034261; P:negative regulation of Ras GTPase activity; IEA:Compara.
 GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:Compara.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
 GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:UniProtKB.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IMP:UniProtKB.
 GO:0007605; P:sensory perception of sound; IEA:Compara. 

Interpro

 IPR007875; Sprouty. 

Pfam

 PF05210; Sprouty 

SMART

  

PROSITE

 PS51227; SPR 

PRINTS