UniProt Accession

 DHSB_ECOLI; P07014 

Genbank Protein ID

 J01619; X01070; U00096; AP009048; X00661 

Genbank Nucleotide ID

 AAA23896.1; CAA25534.1; AAC73818.1; BAA35391.1; CAA25279.1 

Protein Name

 Succinate dehydrogenase iron-sulfur subunit 

Protein Synonyms/Alias

  

Gene Name

 sdhB 

Gene Synonyms/Alias

 b0724; JW0714 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
45	ALIQLKEKDPSLSFR	acetylation	[1]
116	QFYAQYEKIKPYLLN	acetylation	[1]
118	YAQYEKIKPYLLNNG	acetylation	[1]
230	TRAIGHIKSMLLQRN	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. 

Sequence Annotation

 DOMAIN 8 97 2Fe-2S ferredoxin-type.
 DOMAIN 139 169 4Fe-4S ferredoxin-type.
 METAL 55 55 Iron-sulfur 1 (2Fe-2S).
 METAL 60 60 Iron-sulfur 1 (2Fe-2S).
 METAL 75 75 Iron-sulfur 1 (2Fe-2S).
 METAL 149 149 Iron-sulfur 2 (4Fe-4S).
 METAL 152 152 Iron-sulfur 2 (4Fe-4S).
 METAL 155 155 Iron-sulfur 2 (4Fe-4S).
 METAL 159 159 Iron-sulfur 3 (3Fe-4S).
 METAL 206 206 Iron-sulfur 3 (3Fe-4S).
 METAL 212 212 Iron-sulfur 3 (3Fe-4S).
 METAL 216 216 Iron-sulfur 2 (4Fe-4S).
 BINDING 164 164 Ubiquinone; shared with SdhD subunit.  

Keyword

 2Fe-2S; 3D-structure; 3Fe-4S; 4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Oxidoreductase; Reference proteome; Transport; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 238 AA 

Protein Sequence

Gene Ontology

 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0051537; F:2 iron, 2 sulfur cluster binding; IMP:EcoCyc.
 GO:0051538; F:3 iron, 4 sulfur cluster binding; IDA:EcoCyc.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IMP:EcoCyc.
 GO:0009055; F:electron carrier activity; IMP:EcoCyc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0000104; F:succinate dehydrogenase activity; IEA:EC.
 GO:0009060; P:aerobic respiration; IEP:EcoCyc.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. 

Interpro

 IPR001041; 2Fe-2S_ferredoxin-type.
 IPR017896; 4Fe4S_Fe-S-bd.
 IPR017900; 4Fe4S_Fe_S_CS.
 IPR012675; Beta-grasp_dom.
 IPR012285; Fum_reductase_C.
 IPR009051; Helical_ferredxn.
 IPR004489; Succ_DH/fum_Rdtase_Fe-S.
 IPR025192; Succ_DH/fum_Rdtase_N. 

Pfam

 PF13085; Fer2_3 

SMART

  

PROSITE

 PS00197; 2FE2S_FER_1
 PS51085; 2FE2S_FER_2
 PS00198; 4FE4S_FER_1
 PS51379; 4FE4S_FER_2 

PRINTS