CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030807
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ryanodine receptor 2 
Protein Synonyms/Alias
 cDNA FLJ54506, highly similar to Ryanodine receptor 2 
Gene Name
 RYR2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
252IDEGAWMKRLAVFSQubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Receptor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1421 AA 
Protein Sequence
MKTGLESVKS ALRAFLDNAA EDLEKTMENL KQGQFTHTRN QPKGVTQIIN YTTVALLPML 60
SSLFEHIGQH QFGEDLILED VQVSCYRILT SLYALGTSKS IYVERQRSAL GECLAAFAGA 120
FPVAFLETHL DKHNIYSIYN TKSSRERAAL SLPTNVEDVC PNIPSLEKLM EEIVELAESG 180
IRYTQMPHVM EVILPMLCSY MSRWWEHGPE NNPERAEMCC TALNSEHMNT LLGNILKIIY 240
NNLGIDEGAW MKRLAVFSQP IINKVKPQLL KTHFLPLMEK LKKKAATVVS EEDHLKAEAR 300
GDMSEAELLI LDEFTTLARD LYAFYPLLIR FVDYNRAKWL KEPNPEAEEL FRMVAEVFIY 360
WSKSHNFKRE EQNFVVQNEI NNMSFLITDT KSKMSKAAVS DQERKKMKRK GDRYSMQTSL 420
IVAALKRLLP IGLNICAPGD QELIALAKNR FSLKDTEDEV RDIIRSNIHL QGKLEDPAIR 480
WQMALYKDLP NRTDDTSDPE KTVERVLDIA NVLFHLEQKS KRVGRRHYCL VEHPQRSKKA 540
VWHKLLSKQR KRAVVACFRM APLYNLPRHR AVNLFLQGYE KSWIETEEHY FEDKLIEDLA 600
KPGAEPPEED EGTKRVDPLH QLILLFSRTA LTEKCKLEED FLYMAYADIM AKSCHDEEDD 660
DGEEEVKSFE HDIIKDLRNK FASLGENSLE KEMEKQKLLY QQARLHDRGA AEMVLQTISA 720
SKGETGPMVA ATLKLGIAIL NGGNSTVQQK MLDYLKEKKD VGFFQSLAGL MQSCSVLDLN 780
AFERQNKAEG LGMVTEEGSG EKVLQDDEFT CDLFRFLQLL CEGHNSDFQN YLRTQTGNNT 840
TVNIIISTVD YLLRVQESIS DFYWYYSGKD VIDEQGQRNF SKAIQVAKQV FNTLTEYIQG 900
PCTGNQQSLA HSRLWDAVVG FLHVFAHMQM KLSQDSSQIE LLKELMDLQK DMVVMLLSML 960
EGNVVNGTIG KQMVDMLVES SNNVEMILKF FDMFLKLKDL TSSDTFKEYD PDGKGVISKR 1020
DFHKAMESHK HYTQSETEFL LSCAETDENE TLDYEEFVKR FHEPAKDIGF NVAVLLTNLS 1080
EHMPNDTRLQ TFLELAESVL NYFQPFLGRI EIMGSAKRIE RVYFEISESS RTQWEKPQVK 1140
ESKRQFIFDV VNEGGEKEKM ELFVNFCEDT IFEMQLAAQI SESDLNERSA NKEESEKERP 1200
EEQGPRMAFF SILTVRSALF ALRYNILTLM RMLSLKSLKK QMKKVKKMTV KDMVTAFFSS 1260
YWSIFMTLLH FVASVFRGFF RIICSLLLGG SLVEGAKKIK VAELLANMPD PTQDEVRGDG 1320
EEGERKPLEA ALPSEDLTDL KELTEESDLL SDIFGLDLKR EGGQYKLIPH NPNAGLSDLM 1380
SNPVPMPEVQ EKFQEQKAKE EEKEEKEETK SEPEKAEGED G 1421 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:InterPro. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom.
 IPR013662; RIH_assoc-dom.
 IPR009460; Ryanrecept_TM4-6. 
Pfam
 PF08454; RIH_assoc
 PF06459; RR_TM4-6 
SMART
 SM00054; EFh 
PROSITE
 PS50222; EF_HAND_2 
PRINTS