| Tag | Content |
|---|
| CPLM ID | CPLM-000983 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein-tyrosine sulfotransferase 2 |
Protein Synonyms/Alias | Tyrosylprotein sulfotransferase 2; TPST-2 |
Gene Name | TPST2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 158 | PARVLCNKDPFTLKS | ubiquitination | [1] | | 291 | RSTDQVIKPVNLEAL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides. |
Sequence Annotation | CARBOHYD 343 343 N-linked (GlcNAc...) (Potential).
CARBOHYD 368 368 N-linked (GlcNAc...) (Potential). |
Keyword | 3D-structure; Complete proteome; Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 377 AA |
Protein Sequence | MRLSVRRVLL AAGCALVLVL AVQLGQQVLE CRAVLAGLRS PRGAMRPEQE ELVMVGTNHV 60
EYRYGKAMPL IFVGGVPRSG TTLMRAMLDA HPEVRCGEET RIIPRVLAMR QAWSKSGREK 120
LRLDEAGVTD EVLDAAMQAF ILEVIAKHGE PARVLCNKDP FTLKSSVYLS RLFPNSKFLL 180
MVRDGRASVH SMITRKVTIA GFDLSSYRDC LTKWNKAIEV MYAQCMEVGK EKCLPVYYEQ 240
LVLHPRRSLK LILDFLGIAW SDAVLHHEDL IGKPGGVSLS KIERSTDQVI KPVNLEALSK 300
WTGHIPGDVV RDMAQIAPML AQLGYDPYAN PPNYGNPDPF VINNTQRVLK GDYKTPANLK 360
GYFQVNQNST SSHLGSS 377 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016020; C:membrane; TAS:ProtInc. GO:0008476; F:protein-tyrosine sulfotransferase activity; TAS:ProtInc. GO:0007342; P:fusion of sperm to egg plasma membrane; IEA:Compara. GO:0006478; P:peptidyl-tyrosine sulfation; TAS:ProtInc. GO:0060468; P:prevention of polyspermy; IEA:Compara. |
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Pfam | |
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PRINTS | |