UniProt Accession

 PTGR1_HUMAN; Q14914; A8K0N2; B4DPK3; F5GY50; Q8IYQ0; Q9H1X6 

Genbank Protein ID

 AK289597; AK298379; AL135787; AL159168; CH471105; BC035228; D49387 

Genbank Nucleotide ID

 BAF82286.1; BAG60615.1; CAC22151.1; EAW59074.1; AAH35228.1; BAA08382.1 

Protein Name

 Prostaglandin reductase 1 

Protein Synonyms/Alias

 PRG-1; 15-oxoprostaglandin 13-reductase; NADP-dependent leukotriene B4 12-hydroxydehydrogenase 

Gene Name

 PTGR1 

Gene Synonyms/Alias

 LTB4DH 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
58	RVAAKRLKEGDTMMG	ubiquitination	[1]
70	MMGQQVAKVVESKNV	ubiquitination	[1]
178	GAVGSDEKVAYLQKL	ubiquitination	[1]
204	ESLEETLKKASPDGY	ubiquitination	[1]
289	KALKDLLKWVLEGKI	acetylation	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. 

Sequence Annotation

 NP_BIND 152 155 NADP.
 NP_BIND 239 245 NADP.
 NP_BIND 270 272 NADP.
 BINDING 178 178 NADP.
 BINDING 193 193 NADP.
 BINDING 217 217 NADP.
 BINDING 321 321 NADP.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 329 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; NAS:UniProtKB.
 GO:0036132; F:13-prostaglandin reductase activity; IEA:EC.
 GO:0047522; F:15-oxoprostaglandin 13-oxidase activity; IEA:EC.
 GO:0032440; F:2-alkenal reductase [NAD(P)] activity; IEA:EC.
 GO:0004022; F:alcohol dehydrogenase (NAD) activity; NAS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0019371; P:cyclooxygenase pathway; TAS:Reactome.
 GO:0006691; P:leukotriene metabolic process; NAS:UniProtKB.
 GO:2001300; P:lipoxin metabolic process; TAS:Reactome.
 GO:0009636; P:response to toxic substance; IEA:Compara. 

Interpro

 IPR013149; ADH_C.
 IPR002085; ADH_SF_Zn-type.
 IPR014190; B4_12hDH.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00107; ADH_zinc_N 

SMART

  

PROSITE

  

PRINTS