| Tag | Content |
|---|
| CPLM ID | CPLM-017465 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cleavage and polyadenylation specificity factor subunit 7 |
Protein Synonyms/Alias | Cleavage and polyadenylation specificity factor 59 kDa subunit; CFIm59; CPSF 59 kDa subunit; Pre-mRNA cleavage factor Im 59 kDa subunit |
Gene Name | CPSF7 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 148 | LLELLPGKVLNGEKV | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3' processing. Binds to cleavage and polyadenylation RNA substrates. |
Sequence Annotation | DOMAIN 82 162 RRM.
MOD_RES 203 203 Phosphothreonine.
MOD_RES 413 413 Phosphoserine.
MOD_RES 423 423 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; mRNA processing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 471 AA |
Protein Sequence | MSEGVDLIDI YADEEFNQDP EFNNTDQIDL YDDVLTATSQ PSDDRSSSTE PPPPVRQEPS 60
PKPNNKTPAI LYTYSGLRNR RAAVYVGSFS WWTTDQQLIQ VIRSIGVYDV VELKFAENRA 120
NGQSKGYAEV VVASENSVHK LLELLPGKVL NGEKVDVRPA TRQNLSQFEA QARKRECVRV 180
PRGGIPPRAH SRDSSDSADG RATPSENLVP SSARVDKPPS VLPYFNRPPS ALPLMGLPPP 240
PIPPPPPLSS SFGVPPPPPG IHYQHLMPPP PRLPPHLAVP PPGAIPPALH LNPAFFPPPN 300
ATVGPPPDTY MKASAPYNHH GSRDSGPPPS TVSEAEFEDI MKRNRAISSS AISKAVSGAS 360
AGDYSDAIET LLTAIAVIKQ SRVANDERCR VLISSLKDCL HGIEAKSYSV GASGSSSRKR 420
HRSRERSPSR SRESSRRHRD LLHNEDRHDD YFQERNREHE RHRDRERDRH H 471 |
Gene Ontology | GO:0005849; C:mRNA cleavage factor complex; IDA:UniProtKB. GO:0000166; F:nucleotide binding; IEA:InterPro. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0031124; P:mRNA 3'-end processing; TAS:Reactome. GO:0000398; P:mRNA splicing, via spliceosome; TAS:Reactome. GO:0051262; P:protein tetramerization; IDA:UniProtKB. GO:0006369; P:termination of RNA polymerase II transcription; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |