CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020429
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tripartite motif-containing protein 4 
Protein Synonyms/Alias
 RING finger protein 87 
Gene Name
 TRIM4 
Gene Synonyms/Alias
 RNF87 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
73ALARLTEKTQRRRLGubiquitination[1]
157HLQDVEVKNATQWKDubiquitination[2]
221NQTIASLKKLILEVGubiquitination[2]
243LELLQNPKEVLTRSEubiquitination[2]
262NYSLEAVKVKTVCQIubiquitination[2]
353KNVFTSGKHYWEVESubiquitination[2]
Reference
 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
 DOMAIN 288 500 B30.2/SPRY.
 ZN_FING 12 53 RING-type.
 ZN_FING 82 123 B box-type.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Metal-binding; Polymorphism; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 500 AA 
Protein Sequence
MEAEDIQEEL TCPICLDYFQ DPVSIECGHN FCRGCLHRNW APGGGPFPCP ECRHPSAPAA 60
LRPNWALARL TEKTQRRRLG PVPPGLCGRH WEPLRLFCED DQRPVCLVCR ESQEHQTHAM 120
APIDEAFESY REKLLKSQRN LVAKMKKVMH LQDVEVKNAT QWKDKIKSQR MRISTEFSKL 180
HNFLVEEEDL FLQRLNKEEE ETKKKLNENT LKLNQTIASL KKLILEVGEK SQAPTLELLQ 240
NPKEVLTRSE IQDVNYSLEA VKVKTVCQIP LMKEMLKRFQ VAVNLAEDTA HPKLVFSQEG 300
RYVKNTASAS SWPVFSSAWN YFAGWRNPQK TAFVERFQHL PCVLGKNVFT SGKHYWEVES 360
RDSLEVAVGV CREDVMGITD RSKMSPDVGI WAIYWSAAGY WPLIGFPGTP TQQEPALHRV 420
GVYLDRGTGN VSFYSAVDGV HLHTFSCSSV SRLRPFFWLS PLASLVIPPV TDRK 474 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0070206; P:protein trimerization; IDA:UniProtKB. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR003879; Butyrophylin.
 IPR008985; ConA-like_lec_gl_sf.
 IPR003877; SPRY_rcpt.
 IPR000315; Znf_B-box.
 IPR018957; Znf_C3HC4_RING-type.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF00622; SPRY
 PF00643; zf-B_box
 PF00097; zf-C3HC4 
SMART
 SM00336; BBOX
 SM00184; RING 
PROSITE
 PS50188; B302_SPRY
 PS50119; ZF_BBOX
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS
 PR01407; BUTYPHLNCDUF.