CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036871
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Latent-transforming growth factor beta-binding protein 4 
Protein Synonyms/Alias
  
Gene Name
 LTBP4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1228LFRDQVCKSGVCVNTubiquitination[1, 2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; EGF-like domain; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1586 AA 
Protein Sequence
MGDVKALLFV AAARARRLGG AAASESLAVS EAFCRVRSCQ PKKCAGPQRC LNPVPAVPSP 60
SPSVRKRQVS LNWQPLTLQE ARALLKRRRP RGPGGRGLLR RRPPQRAPAG KAPVLCPLIC 120
HNGGVCVKPD RCLCPPDFAG KFCQLHSSGA RPPAPAVPGL TRSVYTMPLA NHRDDEHGVA 180
SMVSVHVEHP QEASVVVHQV ERVSGPWEEA DAEAVARAEA AARAEAAAPY TVLAQSAPRE 240
DGYSDASGFG YCFRELRGGE CASPLPGLRT QEVCCRGAGL AWGVHDCQLC SERLGNSERV 300
SAPDGPCPTG FERVNGSCED VDECATGGRC QHGECANTRG GYTCVCPDGF LLDSSRSSCI 360
SQHVISEAKG PCFRVLRDGG CSLPILRNIT KQICCCSRVG KAWGRGCQLC PPFGSEGFRE 420
ICPAGPGYHY SASDLRYNTR PLGQEPPRVS LSQPRTLPAT SRPSAGFLPT HRLEPRPEPR 480
PDPRPGPELP LPSIPAWTGP EIPESGPSSG MCQRNPQVCG PGRCISRPSG YTCACDSGFR 540
LSPQGTRCID VDECRRVPPP CAPGRCENSP GSFRCVCGPG FRAGPRAAEC LDVDECHRVP 600
PPCDLGRCEN TPGSFLCVCP AGYQAAPHGA SCQDVDECTQ SPGLCGRGAC KNLPGSFRCV 660
CPAGFRGSAC EEDVDECAQE PPPCGPGRCD NTAGSFHCAC PAGFRSRGPG APCQDVDECA 720
RSPPPCTYGR CENTEGSFQC VCPMGFQPNT AGSECEDVDE CENHLACPGQ ECVNSPGSFQ 780
CRTCPSGHHL HRGRCTDVDE CSSGAPPCGP HGHCTNTEGS FRCSCAPGYR APSGRPGPCA 840
DVNECLEGDF CFPHGECLNT DGSFACTCAP GYRPGPRGAS CLDVDECSEE DLCQSGICTN 900
TDGSFECICP PGHRAGPDLA SCLDVDECRE RGPALCGSQR CENSPGSYRC VRDCDPGYHA 960
GPEGTCDDVD ECQEYGPEIC GAQRCENTPG SYRCTPACDP GYQPTPGGGC QDVDECRNRS 1020
FCGAHAVCQN LPGSFQCLCD QYEGARDGRH CVDVNECETL QGVCGAALCE NVEGSFLCVC 1080
PNSPEEFDPM TGRCVPPRTS AGTFPGSQPQ APASPVLPAR PPPPPLPRRP STPRQGPVGS 1140
GRRECYFDTA APDACDNILA RNVTWQECCC TVGEGWGSGC RIQQCPGTET AEYQSLCPHG 1200
RGYLAPSGDL SLRRDVDECQ LFRDQVCKSG VCVNTAPGYS CYCSNGYYYH TQRLECIDND 1260
ECADEEPACE GGRCVNTVGS YHCTCEPPLV LDGSQRRCVS NESQSLDDNL GVCWQEVGAD 1320
LVCSHPRLDR QATYTECCCL YGEAWGMDCA LCPAQDSDDF EALCNVLRPP AYSPPRPGGF 1380
GLPYEYGPDL GPPYQGLPYG PELYPPPALP YDPYPPPPGP FARREAPYGA PRFDMPDFED 1440
DGGPYGESEA PAPPGPGTRW PYRSRDTRRS FPEPEEPPEG GSYAGSLAEP YEELEAEECG 1500
ILDGCTNGRC VRVPEGFTCR CFDGYRLDMT RMACVDINEC DEAEAASPLC VNARCLNTDG 1560
SFRCICRPGF APTHQPHHCA PARPRA 1586 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro. 
Interpro
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR017878; TB_dom. 
Pfam
 PF07645; EGF_CA
 PF00683; TB 
SMART
 SM00181; EGF
 SM00179; EGF_CA 
PROSITE
 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS51364; TB 
PRINTS