UniProt Accession

 T2EA_MOUSE; Q9D0D5; Q544T0 

Genbank Protein ID

 AK011543; AK031528; AK154283; BC056966 

Genbank Nucleotide ID

 BAB27686.1; BAC27436.1; BAE32487.1; AAH56966.1 

Protein Name

 General transcription factor IIE subunit 1 

Protein Synonyms/Alias

 General transcription factor IIE 56 kDa subunit; Transcription initiation factor IIE subunit alpha; TFIIE-alpha 

Gene Name

 Gtf2e1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
19	AALKRLAKYVIRGFY	acetylation	[1]
44	LIRNPCVKEEDMLEL	acetylation	[1]
67	RSVLNNLKGDKFIKC	acetylation	[2, 3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. 

Sequence Annotation

 DOMAIN 14 104 HTH TFE/IIEalpha-type.
 ZN_FING 129 157 C4-type (Potential).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 67 67 N6-acetyllysine (By similarity).
 MOD_RES 268 268 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 440 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:InterPro. 

Interpro

 IPR017919; TFIIE/TFIIEa_HTH.
 IPR002853; TFIIE_asu.
 IPR021600; TFIIE_asu_C.
 IPR024550; TFIIEa/SarR/Rpc3_HTH_dom.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR013137; Znf_TFIIB. 

Pfam

 PF08271; TF_Zn_Ribbon
 PF11521; TFIIE-A_C-term
 PF02002; TFIIE_alpha 

SMART

 SM00531; TFIIE 

PROSITE

 PS51344; HTH_TFE_IIE 

PRINTS