CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044914
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Envoplakin 
Protein Synonyms/Alias
  
Gene Name
 EVPL 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
383QQLEAEEKRLAVTERubiquitination[1, 2]
500ATVQSRLKASAVESLubiquitination[2]
1473LRIQELEKRPPTVQEubiquitination[3]
1522TELNRECKNLQVQIDubiquitination[2]
1533VQIDVLQKAKSQEKTubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2055 AA 
Protein Sequence
MFKGLSKGSQ GKGSPKGSPA KGSPKGSPSR HSRAATQELA LLISRMQANA DQVERDILET 60
QKRLQQDRLN SEQSQALQHQ QETGRSLKEA EVLLKDLFLD VDKARRLKHP QAEEIEKDIK 120
QLHERVTQEC AEYRALYEKM VLPPDVGPRV DWARVLEQKQ KQVCAGQYGP GMAELEQQIA 180
EHNILQKEID AYGQQLRSLV GPDAATIRSQ YRDLLKAASW RGQSLGSLYT HLQGCTRQLS 240
ALAEQQRRIL QQDWSDLMAD PAGVRREYEH FKQHELLSQE QSVNQLEDDG ERMVELRHPA 300
VGPIQAHQEA LKMEWQNFLN LCICQETQLQ HVEDYRRFQE EADSVSQTLA KLNSNLDAKY 360
SPAPGGPPGA PTELLQQLEA EEKRLAVTER ATGDLQRRSR DVAPLPQRRN PPQQPLHVDS 420
ICDWDSGEVQ LLQGERYKLV DNTDPHAWVV QGPGGETKRA PAACFCIPAP DPDAVARASR 480
LASELQALKQ KLATVQSRLK ASAVESLRPS QQGTQGGPGR GGCGARRSRF RLPTAPSGSD 540
LANPQAQKLL TQMTRLDGDL GQIERQVLAW ARAPLSRPTP LEDLEGRIHS HEGTAQRLQS 600
LGTEKETAQK ECEAFLSTRP VGPAALQLPV ALNSVKNKFS DVQVLCSLYG EKAKAALDLE 660
RQIQDADRVI RGFEATLVQE APIPAEPGAL QERVSELQRQ RRELLEQQTC VLRLHRALKA 720
SEHACAALQN NFQEFCQDLP RQQRQVRALT DRYHAVGDQL DLREKVVQDA ALTYQQFKNC 780
KDNLSSWLEH LPRSQVRPSD GPSQIAYKLQ AQKRLTQEIQ SRERDRATAS HLSQALQAAL 840
QDYELQADTY RCSLEPTLAV SAPKRPRVAP LQESIQAQEK NLAKAYTEVA AAQQQLLQQL 900
EFARKMLEKK ELSEDIRRTH DAKQGSESPA QAGRESEALK AQLEEERKRV ARVQHELEAQ 960
RSQLLQLRTQ RPLERLEEKE VVEFYRDPQL EGSLSRVKAQ VEEEGKRRAG LQADLEVAAQ 1020
KVVQLESKRK TMQPHLLTKE VTQVERDPGL DSQAAQLRIQ IQQLRGEDAV ISARLEGLKK 1080
ELLALEKREV DVKEKVVVKE VVKVEKNLEM VKAAQALRLQ MEEDAARRKQ AEEAVAKLQA 1140
RIEDLERAIS SVEPKVIVKE VKKVEQDPGL LQESSRLRSL LEEERTKNAT LARELSDLHS 1200
KYSVVEKQRP KVQLQERVHE IFQVDPETEQ EITRLKAKLQ EMAGKRSGVE KEVEKLLPDL 1260
EVLRAQKPTV EYKEVTQEVV RHERSPEVLR EIDRLKAQLN ELVNSHGRSQ EQLIRLQGER 1320
DEWRRERAKV ETKTVSKEVV RHEKDPVLEK EAERLRQEVR EAAQKRRAAE DAVYELQSKR 1380
LLLERRKPEE KVVVQEVVVT QKDPKLREEH SRLSGSLDEE VGRRRQLELE VQQLRAGVEE 1440
QEGLLSFQED RSKKLAVERE LRQLTLRIQE LEKRPPTVQE KIIMEEVVKL EKDPDLEKST 1500
EALRWDLDQE KTQVTELNRE CKNLQVQIDV LQKAKSQEKT IYKEVIRVQK DRVLEDERAR 1560
VWEMLNRERT ARQAREEEAR RLRERIDRAE TLGRTWSREE SELQRARDQA DQECGRLQQE 1620
LRALERQKQQ QTLQLQEESK LLSQKTESER QKAAQRGQEL SRLEAAILRE KDQIYEKERT 1680
LRDLHAKVSR EELSQETQTR ETNLSTKISI LEPETGKDMS PYEAYKRGII DRGQYLQLQE 1740
LECDWEEVTT SGPCGEESVL LDRKSGKQYS IEAALRCRRI SKEEYHLYKD GHLPISEFAL 1800
LVAGETKPSS SLSIGSIISK SPLASPAPQS TSFFSPSFSL GLGDDSFPIA GIYDTTTDNK 1860
CSIKTAVAKN MLDPITGQKL LEAQAATGGI VDLLSRERYS VHKAMERGLI ENTSTQRLLN 1920
AQKAFTGIED PVTKKRLSVG EAVQKGWMPR ESVLPHLQVQ HLTGGLIDPK RTGRIPIQQA 1980
LLSGMISEEL AQLLQDESSY EKDLTDPISK ERLSYKEAMG RCRKDPLSGL LLLPAALEGY 2040
RCYRSASPTV PRSLR 2055 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:InterPro. 
Interpro
 IPR001101; Plectin_repeat.
 IPR018159; Spectrin/alpha-actinin. 
Pfam
 PF00681; Plectin 
SMART
 SM00250; PLEC
 SM00150; SPEC 
PROSITE
  
PRINTS