UniProt Accession

 DNJB4_HUMAN; Q9UDY4; B2R824; Q13431 

Genbank Protein ID

 U40992; AK313205; CH471059; BC034721; U41290 

Genbank Nucleotide ID

 AAC14483.2; BAG36021.1; EAX06354.1; AAH34721.1; AAB07346.1 

Protein Name

 DnaJ homolog subfamily B member 4 

Protein Synonyms/Alias

 Heat shock 40 kDa protein 1 homolog; HSP40 homolog; Heat shock protein 40 homolog; Human liver DnaJ-like protein 

Gene Name

 DNAJB4 

Gene Synonyms/Alias

 DNAJW; HLJ1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
73	QFGEEGLKGGAGGTD	ubiquitination	[1, 2]
302	GYGLPFPKNPDQRGD	ubiquitination	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Probable chaperone. 

Sequence Annotation

 DOMAIN 2 70 J.
 MOD_RES 122 122 Phosphoserine.
 MOD_RES 148 148 Phosphoserine.  

Keyword

 Cell membrane; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome; Stress response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 337 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0051082; F:unfolded protein binding; TAS:ProtInc.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0009408; P:response to heat; TAS:ProtInc.
 GO:0006986; P:response to unfolded protein; TAS:ProtInc. 

Interpro

 IPR002939; DnaJ_C.
 IPR001623; DnaJ_domain.
 IPR018253; DnaJ_domain_CS.
 IPR008971; HSP40/DnaJ_pept-bd. 

Pfam

 PF00226; DnaJ
 PF01556; DnaJ_C 

SMART

 SM00271; DnaJ 

PROSITE

 PS00636; DNAJ_1
 PS50076; DNAJ_2 

PRINTS

 PR00625; JDOMAIN.