CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027833
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alpha-tubulin N-acetyltransferase 
Protein Synonyms/Alias
 Alpha-TAT; TAT; Acetyltransferase mec-17 homolog 
Gene Name
 Atat1 
Gene Synonyms/Alias
 Mec17 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
21TSARPAGKGAIIGFLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development (By similarity). 
Sequence Annotation
 REGION 55 68 Acetyl-CoA binding (By similarity).
 REGION 91 100 Acetyl-CoA binding (By similarity).  
Keyword
 Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 254 AA 
Protein Sequence
MQSNRHVIYI LKDTSARPAG KGAIIGFLKV GYKKLFVLDD REAHNEVEPL CILDFYIHES 60
VQRHGHGREL FQHMLQKERV EPHQLAIDRP SPKLLKFLNK HYNLETTVPQ VNNFVIFEGF 120
FAHQHRPPTS SLRATRHSRA AVADPIPAGK ACKDWVELKA VRPSSSGGSR VAVLSAGNSE 180
HPKATHPSSS AVCPGPAGSI LHMGRNQIPA NAQAHTLTTL PYSKAHPALF SATVLTKQAL 240
QELGWPPVSA EPLR 254 
Gene Ontology
 GO:0019799; F:tubulin N-acetyltransferase activity; IEA:HAMAP.
 GO:0071929; P:alpha-tubulin acetylation; IEA:InterPro.
 GO:0048666; P:neuron development; IEA:HAMAP.
 GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:HAMAP. 
Interpro
 IPR016181; Acyl_CoA_acyltransferase.
 IPR007965; Alpha-TAT. 
Pfam
 PF05301; Mec-17 
SMART
  
PROSITE
  
PRINTS