CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004503
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Growth hormone receptor 
Protein Synonyms/Alias
 GH receptor; Somatotropin receptor; Growth hormone-binding protein; GH-binding protein; GHBP; Serum-binding protein 
Gene Name
 Ghr 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
303FSKQQRIKMLILPPVubiquitination[1]
314LPPVPVPKIKGIDPDubiquitination[1]
316PVPVPKIKGIDPDLLubiquitination[1]
324GIDPDLLKEGKLEEVubiquitination[1]
383LLSNDHEKSAGILGAubiquitination[1]
440DLLCLDQKNLKNLPYubiquitination[1]
519LSPGQKIKAGIAQGNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). 
Sequence Annotation
 DOMAIN 157 257 Fibronectin type-III.
 REGION 303 390 Required for JAK2 binding (By
 MOTIF 248 252 WSXWS motif.
 MOTIF 306 314 Box 1 motif.
 MOTIF 349 358 UbE motif.
 CARBOHYD 123 123 N-linked (GlcNAc...) (Potential).
 CARBOHYD 164 164 N-linked (GlcNAc...) (Potential).
 CARBOHYD 169 169 N-linked (GlcNAc...) (Potential).
 CARBOHYD 208 208 N-linked (GlcNAc...) (Potential).
 DISULFID 56 66 By similarity.
 DISULFID 109 120 By similarity.
 DISULFID 134 148 By similarity.  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Endocytosis; Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 650 AA 
Protein Sequence
MDLCQVFLTL ALAVTSSTFS GSEATPATLG KASPVLQRIN PSLGTSSSGK PRFTKCRSPE 60
LETFSCYWTE GDNPDLKTPG SIQLYYAKRE SQRQAARIAH EWTQEWKECP DYVSAGKNSC 120
YFNSSYTSIW IPYCIKLTTN GDLLDQKCFT VDEIVQPDPP IGLNWTLLNI SLTGIRGDIQ 180
VSWQPPPNAD VLKGWIILEY EIQYKEVNES KWKVMGPIWL TYCPVYSLRM DKEHEVRVRS 240
RQRSFEKYSE FSEVLRVIFP QTNILEACEE DIQFPWFLII IFGIFGVAVM LFVVIFSKQQ 300
RIKMLILPPV PVPKIKGIDP DLLKEGKLEE VNTILGIHDN YKPDFYNDDS WVEFIELDID 360
EADVDEKTEG SDTDRLLSND HEKSAGILGA KDDDSGRTSC YDPDILDTDF HTSDMCDGTL 420
KFRQSQKLNM EADLLCLDQK NLKNLPYDAS LGSLHPSITQ TVEENKPQPL LSSETEATHQ 480
LASTPMSNPT SLANIDFYAQ VSDITPAGGD VLSPGQKIKA GIAQGNTQRE VATPCQENYS 540
MNSAYFCESD AKKCIAVARR MEATSCIKPS FNQEDIYITT ESLTTTAQMS ETADIAPDAE 600
MSVPDYTTVH TVQSPRGLIL NATALPLPDK KNFPSSCGYV STDQLNKIMQ 650 
Gene Ontology
 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0019898; C:extrinsic to membrane; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0004903; F:growth hormone receptor activity; IDA:MGI.
 GO:0017046; F:peptide hormone binding; IPI:MGI.
 GO:0006103; P:2-oxoglutarate metabolic process; IMP:BHF-UCL.
 GO:0000255; P:allantoin metabolic process; IMP:BHF-UCL.
 GO:0006101; P:citrate metabolic process; IMP:BHF-UCL.
 GO:0006600; P:creatine metabolic process; IMP:BHF-UCL.
 GO:0046449; P:creatinine metabolic process; IMP:BHF-UCL.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0006631; P:fatty acid metabolic process; IMP:BHF-UCL.
 GO:0060396; P:growth hormone receptor signaling pathway; IDA:BHF-UCL.
 GO:0006549; P:isoleucine metabolic process; IMP:BHF-UCL.
 GO:0006107; P:oxaloacetate metabolic process; IMP:BHF-UCL.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL.
 GO:0040014; P:regulation of multicellular organism growth; IDA:BHF-UCL.
 GO:0006105; P:succinate metabolic process; IMP:BHF-UCL.
 GO:0019530; P:taurine metabolic process; IMP:BHF-UCL.
 GO:0006573; P:valine metabolic process; IMP:BHF-UCL. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR025871; GHBP.
 IPR015152; Growth/epo_recpt_lig-bind.
 IPR013783; Ig-like_fold.
 IPR003528; Long_hematopoietin_rcpt_CS. 
Pfam
 PF09067; EpoR_lig-bind
 PF12772; GHBP 
SMART
 SM00060; FN3 
PROSITE
 PS50853; FN3
 PS01352; HEMATOPO_REC_L_F1 
PRINTS