UniProt Accession

 FBRL_RAT; P22509; Q4KLH8 

Genbank Protein ID

 BC099198 

Genbank Nucleotide ID

 AAH99198.1 

Protein Name

 rRNA 2'-O-methyltransferase fibrillarin 

Protein Synonyms/Alias

 Nucleolar protein 1 

Gene Name

 Fbl 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
108	GVFICRGKEDALVTK	acetylation	[1]
127	GESVYGEKRVSISEG	acetylation	[1]
211	RDLINLAKKRTNIIP	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). 

Sequence Annotation

 REGION 178 179 S-adenosyl-L-methionine binding (By
 REGION 197 198 S-adenosyl-L-methionine binding (By
 REGION 222 223 S-adenosyl-L-methionine binding (By
 BINDING 149 149 S-adenosyl-L-methionine (By similarity).
 BINDING 242 242 S-adenosyl-L-methionine (By similarity).
 MOD_RES 8 8 Asymmetric dimethylarginine.
 MOD_RES 15 15 Asymmetric dimethylarginine.
 MOD_RES 21 21 Asymmetric dimethylarginine.
 MOD_RES 24 24 Asymmetric dimethylarginine.
 MOD_RES 28 28 Asymmetric dimethylarginine.
 MOD_RES 31 31 Asymmetric dimethylarginine.
 MOD_RES 130 130 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Direct protein sequencing; Methylation; Methyltransferase; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; RNA-binding; rRNA processing; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; IEA:Compara.
 GO:0001651; C:dense fibrillar component; IDA:UniProtKB.
 GO:0001652; C:granular component; IEA:Compara.
 GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IDA:UniProtKB.
 GO:0006396; P:RNA processing; IDA:UniProtKB.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
 GO:0016074; P:snoRNA metabolic process; IEA:Compara.
 GO:0008033; P:tRNA processing; IEA:InterPro. 

Interpro

 IPR000692; Fibrillarin.
 IPR020813; Fibrillarin_CS. 

Pfam

 PF01269; Fibrillarin 

SMART

  

PROSITE

 PS00566; FIBRILLARIN 

PRINTS

 PR00052; FIBRILLARIN.