CPLM-021194

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-021194

UniProt Accession

LHPP_HUMAN; Q9H008; B3KP20; Q2TBE9; Q5VUV9; Q5VUW0

Genbank Protein ID

AB049629; AK055532; AL513190; AL445237; AL513190; AL391708; AL445237; AL391708; AL445237; AL513190; AL445237; AL513190; AL445237; AL391708; AL513190; BC110344; BC113629; BC113631

Genbank Nucleotide ID

BAB16411.1; BAG51532.1; CAH70377.1; CAH70377.1; CAH70378.1; CAH70378.1; CAH70378.1; CAH74011.1; CAH74011.1; CAH74011.1; CAI17295.1; CAI17295.1; CAI17296.1; CAI17296.1; CAI17296.1; AAI10345.1; AAI13630.1; AAI13632.1

Protein Name

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Protein Synonyms/Alias

hLHPP

Gene Name

LHPP

Gene Synonyms/Alias

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
189	IKAEVVGKPSPEFFK	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Phosphatase that hydrolyzes imidodiphosphate, 3- phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).

Sequence Annotation

REGION 17 19 Substrate binding.
REGION 54 55 Substrate binding.
METAL 17 17 Magnesium.
METAL 19 19 Magnesium; via carbonyl oxygen.
METAL 214 214 Magnesium.
BINDING 189 189 Substrate.

Keyword

3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Metal-binding; Nucleus; Polymorphism; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

270 AA

Protein Sequence

MAPWGKRLAG VRGVLLDISG VLYDSGAGGG TAIAGSVEAV ARLKRSRLKV RFCTNESQKS 60
RAELVGQLQR LGFDISEQEV TAPAPAACQI LKEQGLRPYL LIHDGVRSEF DQIDTSNPNC 120
VVIADAGESF SYQNMNNAFQ VLMELEKPVL ISLGKGRYYK ETSGLMLDVG PYMKALEYAC 180
GIKAEVVGKP SPEFFKSALQ AIGVEAHQAV MIGDDIVGDV GGAQRCGMRA LQVRTGKFRP 240
SDEHHPEVKA DGYVDNLAEA VDLLLQHADK 270

Gene Ontology

GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0004427; F:inorganic diphosphatase activity; IDA:UniProtKB.
GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
GO:0008969; F:phosphohistidine phosphatase activity; ISS:UniProtKB.
GO:0006470; P:protein dephosphorylation; ISS:UniProtKB.

Interpro

IPR023214; HAD-like_dom.
IPR006357; HAD-SF_hydro_IIA.
IPR006355; HAD-SF_hydro_IIA_hyp2.
IPR023215; NPhePase-like_dom.

Pfam

PF13344; Hydrolase_6

SMART

PROSITE

PRINTS