UniProt Accession

 KC1E_HUMAN; P49674 

Genbank Protein ID

 L37043; AB024597; AB091043; CR456429; AL020993; BC006490 

Genbank Nucleotide ID

 AAC41761.1; BAA92345.1; BAC10902.1; CAG30315.1; CAA15888.1; AAH06490.1 

Protein Name

 Casein kinase I isoform epsilon 

Protein Synonyms/Alias

 CKI-epsilon; CKIe 

Gene Name

 CSNK1E 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
57	HIESKFYKMMQGGVG	ubiquitination	[1]
122	RIEYIHSKNFIHRDV	ubiquitination	[2]
263	RSLRFDDKPDYSYLR	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation. 

Sequence Annotation

 DOMAIN 9 277 Protein kinase.
 NP_BIND 15 23 ATP (By similarity).
 ACT_SITE 128 128 Proton acceptor (By similarity).
 BINDING 38 38 ATP (By similarity).
 MOD_RES 343 343 Phosphoserine.
 MOD_RES 354 354 Phosphoserine.
 MOD_RES 362 362 Phosphothreonine.
 MOD_RES 363 363 Phosphoserine.
 MOD_RES 389 389 Phosphoserine.  

Keyword

 3D-structure; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 416 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0030529; C:ribonucleoprotein complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; TAS:UniProtKB.
 GO:0034613; P:cellular protein localization; IEA:Compara.
 GO:0006281; P:DNA repair; TAS:ProtInc.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0030178; P:negative regulation of Wnt receptor signaling pathway; IEA:Compara.
 GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

  

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS