CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021120
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphatidylinositide phosphatase SAC1 
Protein Synonyms/Alias
 Suppressor of actin mutations 1-like protein 
Gene Name
 Sacm1l 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
10ATAYEHLKLHITPEKacetylation[1]
315VNHKGSEKPLEQTFAacetylation[1]
456YAGTGALKTDFTRTGacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2. 
Sequence Annotation
 DOMAIN 122 451 SAC.
 MOD_RES 456 456 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Endoplasmic reticulum; Hydrolase; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 587 AA 
Protein Sequence
MAATAYEHLK LHITPEKFYV EACDDGADDV LIIDRVSTEV TLAVKKDVPP SAVTRPIYGI 60
MGTIHLVAGN YLVVITKKMK VGEFFNHVIW KATDFDVLSY KKTMLHLTDI QLQDNKTFLA 120
MLNHVLSTDG FYFSTTYDLT HTLQRLSNTS PEFQEMSLLE RADQRFVWNG HLLRELSAQP 180
EVHRFALPVL HGFITMHSCS INGKYFDWIL ISRRSCFRAG VRYYVRGIDS EGHAANFVET 240
EQIVHYSGNR ASFVQTRGSI PVFWSQRPNL KYKPDPQINK VANHMDGFQR HFDSQVIIYG 300
KQVIINLVNH KGSEKPLEQT FAKMVSSLGS GMIRYIAFDF HKECKNMRWD RLSILLDQVA 360
EMQDELSYFL VDSAGKVVTN QEGVFRSNCM DCLDRTNVIQ SLLARRSLQA QLQRLGVLHV 420
GQKLEEQDEF EKIYKNAWAD NANACAKQYA GTGALKTDFT RTGKRTQLGL VMDGFNSLLR 480
YYKNNFSDGF RQDSIDLFLG NYSVDELDSH SPLSVPRDWK FLALPIIMVV AFSMCIICLL 540
MAGDTWTETL AYVLFWGVAS IGTFFIILYN GKDFVDAPRL VQKEKID 587 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:RGD.
 GO:0034593; F:phosphatidylinositol bisphosphate phosphatase activity; IDA:RGD.
 GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:RGD.
 GO:0043812; F:phosphatidylinositol-4-phosphate phosphatase activity; IDA:RGD.
 GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:RGD. 
Interpro
 IPR002013; Syja_N. 
Pfam
 PF02383; Syja_N 
SMART
  
PROSITE
 PS50275; SAC 
PRINTS