UniProt Accession

 ST1E1_HUMAN; P49888; Q8N6X5 

Genbank Protein ID

 U08098; U20521; U20515; U20516; U20517; U20518; U20519; U20520; S77383; Y11195; AY436634; BC027956; U55764 

Genbank Nucleotide ID

 AAA82125.1; AAC50286.1; AAC50286.1; AAC50286.1; AAC50286.1; AAC50286.1; AAC50286.1; AAC50286.1; AAB34601.1; CAA72079.1; AAQ97179.1; AAH27956.1; AAB51658.1 

Protein Name

 Estrogen sulfotransferase 

Protein Synonyms/Alias

 EST-1; Sulfotransferase 1E1; ST1E1; Sulfotransferase, estrogen-preferring 

Gene Name

 SULT1E1 

Gene Synonyms/Alias

 STE 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
205	DIRKEVIKLIHFLER	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated. 

Sequence Annotation

 NP_BIND 47 52 PAPS.
 NP_BIND 226 231 PAPS.
 NP_BIND 256 258 PAPS.
 REGION 105 107 Substrate binding (By similarity).
 ACT_SITE 107 107 Proton acceptor (By similarity).
 BINDING 129 129 PAPS.
 BINDING 137 137 PAPS.
 BINDING 192 192 PAPS.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Lipid-binding; Polymorphism; Reference proteome; Steroid-binding; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 294 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0004304; F:estrone sulfotransferase activity; TAS:ProtInc.
 GO:0047894; F:flavonol 3-sulfotransferase activity; IDA:BHF-UCL.
 GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
 GO:0050294; F:steroid sulfotransferase activity; IDA:UniProtKB.
 GO:0050427; P:3'-phosphoadenosine 5'-phosphosulfate metabolic process; TAS:Reactome.
 GO:0008210; P:estrogen metabolic process; IDA:UniProtKB.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0051923; P:sulfation; IDA:BHF-UCL.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR000863; Sulfotransferase_dom. 

Pfam

 PF00685; Sulfotransfer_1 

SMART

  

PROSITE

  

PRINTS