CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025850
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transporter 2, ATP-binding cassette, sub-family B isoform 1 variant 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
246LGFFQETKTGELNSRubiquitination[1]
683LQEGKLQKLAQLQEGubiquitination[1, 2, 3]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 704 AA 
Protein Sequence
AMRLPDLRPW TSLLLVDAAL LWLLQGPLGT LLPQGLPGLW LEGTLRLGGL WGLLKLRGLL 60
GFVGTLLLPL CLATPLTVSL RALVAGASRA PPARVASAPW SWLLVGYGAA GLSWSLWAVL 120
SPPGAQEKEQ DQVNNKVLMW RLLKLSRPDL PLLVAAFFFL VLAVLGETLI PHYSGRVIDI 180
LGGDFDPHAF ASAIFFMCLF SFGSSLSAGC RGGCFTYTMS RINLRIREQL FSSLLRQDLG 240
FFQETKTGEL NSRLSSDTTL MSNWLPLNAN VLLRSLVKVV GLYGFMLSIS PRLTLLSLLH 300
MPFTIAAEKV YNTRHQEVLR EIQDAVARAG QVVREAVGGL QTVRSFGAEE HEVCRYKEAL 360
EQCRQLYWRR DLERALYLLV RRVLHLGVQM LMLSCGLQQM QDGELTQGSL LSFMIYQESV 420
GSYVQTLVYI YGDMLSNVGA AEKVFSYMDR QPNLPSPGTL APTTLQGVVK FQDVSFAYPN 480
RPDRPVLKGL TFTLRPGEVT ALVGPNGSGK STVAALLQNL YQPTGGQVLL DEKPISQYEH 540
CYLHSQVVSV GQEPVLFSGS VRNNIAYGLQ SCEDDKVMAA AQAAHADDFI QEMEHGIYTD 600
VGEKGSQLAA GQKQRLAIAR ALVRDPRVLI LDEATSALDV QCEQALQDWN SRGDRTVLVI 660
AHRLQAVQRA HQILVLQEGK LQKLAQLQEG QDLYSRLVQQ RLMD 704 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
 GO:0015197; F:peptide transporter activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR013306; ABC_B3.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR005293; Ag_transporter2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS
 PR01897; TAP2PROTEIN.