CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024281
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TBC1 domain family member 25 
Protein Synonyms/Alias
  
Gene Name
 Tbc1d25 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
208SDVLLAEKRSSLTTAacetylation[1]
344FIRSTVLKDVLRTDRubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Acts as a GTPase-activating protein specific for RAB33B (By similarity). Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes (By similarity). 
Sequence Annotation
 DOMAIN 282 488 Rab-GAP TBC.
 MOD_RES 560 560 Phosphoserine (By similarity).  
Keyword
 Autophagy; Complete proteome; Cytoplasm; Cytoplasmic vesicle; GTPase activation; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 742 AA 
Protein Sequence
MRPPAQARWE GQGPTAPLRL RSGARWGRGR PHCWVYVRVR VTIGYHLDRD DSGGMATTSA 60
ASDSACSAAP PPVGGAQAAA AVEEEEREVV RVRVKKCESF LSPEFRSFAV DPQITSLDVL 120
QHILIRAFDL NGKKNFGISY LARDRLGQET FLSLLSDWDL STAFATASKP YLQLRVDIRP 180
SEDSPLLEDW DIISPKDVIG SDVLLAEKRS SLTTAALPFT QSILSQVGRT LSKVQQVLSW 240
SYGEDVKPFK PPLSDAEFHT YLNHEGQLSR PEELRLRIYH GGVEPSLRKV VWRYLLNVYP 300
DGLTGRERMD YMKRKSREYE QLKSEWAQRV NPEDLEFIRS TVLKDVLRTD RAHPYYAGPE 360
DGPHLRALHD LLTTYAVTHP QVSYCQGMSD LASPILAVMD HEGHAFVCFC GIMKRLAANF 420
HPDGRAMATK FAHLKLLLRH ADPDFYQYLQ EAGADDLFFC YRWLLLELKR EFAFDDALRM 480
LEVTWSSLPP DPPEHEVELV GPPSQVADTG FGSHRGRPVR QRHMLRPAGG GGGAFEDAVV 540
HLAASSQGPS GGGRLLRQAS LDGLQQLRDN MGLRKDHLVQ LSHPATLISS KSLSEPLLNS 600
PDPLLSTSSR PDSPSSSSPP STQEASPSGD IAVGSPLMQE VGSPRDPGKP VPPPPPMGLP 660
PPQEFGRGNP FMLFLCLAIL LEHRDHIMRN GLDYNELAMH FDRLVRKHHL GRVLRRAKAL 720
FADYLQSEVW DSEEGAEATA PS 742 
Gene Ontology
 GO:0005776; C:autophagic vacuole; ISS:UniProtKB.
 GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
 GO:0005097; F:Rab GTPase activator activity; ISS:UniProtKB.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW.
 GO:1901096; P:regulation of autophagic vacuole maturation; ISS:UniProtKB. 
Interpro
 IPR000195; Rab-GTPase-TBC_dom. 
Pfam
 PF00566; RabGAP-TBC 
SMART
 SM00164; TBC 
PROSITE
 PS50086; TBC_RABGAP 
PRINTS