CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016286
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lipolysis-stimulated lipoprotein receptor 
Protein Synonyms/Alias
  
Gene Name
 LSR 
Gene Synonyms/Alias
 LISCH 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
179TVRVVATKQGNAVTLubiquitination[1]
410RVLYYMEKELANFDPubiquitination[1, 2, 3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). 
Sequence Annotation
 DOMAIN 86 234 Ig-like V-type.
 MOD_RES 185 185 Phosphothreonine (By similarity).
 MOD_RES 364 364 Phosphoserine (By similarity).
 MOD_RES 436 436 Phosphoserine (By similarity).
 MOD_RES 493 493 Phosphoserine.
 MOD_RES 528 528 Phosphoserine.
 MOD_RES 530 530 Phosphoserine.
 MOD_RES 535 535 Phosphotyrosine (By similarity).
 MOD_RES 540 540 Phosphoserine.
 MOD_RES 646 646 Phosphoserine (By similarity).
 DISULFID 111 218 By similarity.  
Keyword
 Alternative splicing; Cell membrane; Chylomicron; Complete proteome; Disulfide bond; Immunoglobulin domain; LDL; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Transmembrane; Transmembrane helix; VLDL. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 649 AA 
Protein Sequence
MQQDGLGVGT RNGSGKGRSV HPSWPWCAPR PLRYFGRDAR ARRAQTAAMA LLAGGLSRGL 60
GSHPAAAGRD AVVFVWLLLS TWCTAPARAI QVTVSNPYHV VILFQPVTLP CTYQMTSTPT 120
QPIVIWKYKS FCRDRIADAF SPASVDNQLN AQLAAGNPGY NPYVECQDSV RTVRVVATKQ 180
GNAVTLGDYY QGRRITITGN ADLTFDQTAW GDSGVYYCSV VSAQDLQGNN EAYAELIVLG 240
RTSGVAELLP GFQAGPIEDW LFVVVVCLAA FLIFLLLGIC WCQCCPHTCC CYVRCPCCPD 300
KCCCPEALYA AGKAATSGVP SIYAPSTYAH LSPAKTPPPP AMIPMGPAYN GYPGGYPGDV 360
DRSSSAGGQG SYVPLLRDTD SSVASEVRSG YRIQASQQDD SMRVLYYMEK ELANFDPSRP 420
GPPSGRVERA MSEVTSLHED DWRSRPSRGP ALTPIRDEEW GGHSPRSPRG WDQEPAREQA 480
GGGWRARRPR ARSVDALDDL TPPSTAESGS RSPTSNGGRS RAYMPPRSRS RDDLYDQDDS 540
RDFPRSRDPH YDDFRSRERP PADPRSHHHR TRDPRDNGSR SGDLPYDGRL LEEAVRKKGS 600
EERRRPHKEE EEEAYYPPAP PPYSETDSQA SRERRLKKNL ALSRESLVV 649 
Gene Ontology
 GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; ISS:HGNC.
 GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0009790; P:embryo development; ISS:HGNC.
 GO:0001889; P:liver development; ISS:HGNC.
 GO:0019216; P:regulation of lipid metabolic process; IEA:Compara. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR008664; LISCH7. 
Pfam
 PF05624; LSR 
SMART
 SM00409; IG 
PROSITE
 PS50835; IG_LIKE 
PRINTS