CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034040
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dihydropteridine reductase 
Protein Synonyms/Alias
  
Gene Name
 Qdpr 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
18QVTADVGKLLGDQKVacetylation[1, 2]
18QVTADVGKLLGDQKVsuccinylation[2]
18QVTADVGKLLGDQKVubiquitination[3]
24GKLLGDQKVDAILCVacetylation[2]
24GKLLGDQKVDAILCVsuccinylation[2]
41GWAGGNAKSKSLFKNacetylation[2]
41GWAGGNAKSKSLFKNsuccinylation[2]
43AGGNAKSKSLFKNCDacetylation[4]
47AKSKSLFKNCDMMWKacetylation[1, 2, 4, 5]
47AKSKSLFKNCDMMWKsuccinylation[2]
69ISSHLATKHLKEGGLacetylation[4, 6]
72HLATKHLKEGGLLTLubiquitination[3]
83LLTLAGAKAALDGTPubiquitination[3]
181QVVTTDGKTELTPAYacetylation[2]
181QVVTTDGKTELTPAYsuccinylation[2]
181QVVTTDGKTELTPAYubiquitination[3]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [6] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 189 AA 
Protein Sequence
MTDSFTEQAD QVTADVGKLL GDQKVDAILC VAGGWAGGNA KSKSLFKNCD MMWKQSMWTS 60
TISSHLATKH LKEGGLLTLA GAKAALDGTP GMIGYGMAKG AVHQLCQSLA GKNSGMPPGA 120
AAIAVLPVTL DTPMNRKSMP EADFSSWTPL EFLVETFHDW ITGNKRPNSG SLIQVVTTDG 180
KTELTPAYF 189 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0004155; F:6,7-dihydropteridine reductase activity; IEA:Compara.
 GO:0070404; F:NADH binding; IEA:Compara.
 GO:0070402; F:NADPH binding; IEA:Compara.
 GO:0035690; P:cellular response to drug; IEA:Compara.
 GO:0006559; P:L-phenylalanine catabolic process; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0055114; P:oxidation-reduction process; IEA:GOC.
 GO:0010044; P:response to aluminum ion; IEA:Compara.
 GO:0033762; P:response to glucagon stimulus; IEA:Compara.
 GO:0010288; P:response to lead ion; IEA:Compara.
 GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:Compara. 
Interpro
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 
Pfam
  
SMART
  
PROSITE
 PS00061; ADH_SHORT 
PRINTS