UniProt Accession

 SERPH_MOUSE; P19324; Q5U4D0 

Genbank Protein ID

 X60676; J05609; D12907; AK029080; AK031457; AK077660; AK077937; AK086519; AK086523; AK089993; AK090103; AK159998; AK168442; AK168870; AC158748; BC085143 

Genbank Nucleotide ID

 CAA43091.1; AAA03200.1; BAA02298.1; BAC26283.1; BAC27413.1; BAC36935.1; BAC37075.1; BAC39683.1; BAC39684.1; BAC41032.1; BAC41093.1; BAE35546.1; BAE40347.1; BAE40689.1; AAH85143.1 

Protein Name

 Serpin H1 

Protein Synonyms/Alias

 47 kDa heat shock protein; Collagen-binding protein; Colligin; Serine protease inhibitor J6 

Gene Name

 Serpinh1 

Gene Synonyms/Alias

 Cbp1; Hsp47 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
22	ALAAEVKKPLEAAAP	acetylation	[1]
38	TAEKLSSKATTLAER	acetylation	[2]
38	TAEKLSSKATTLAER	succinylation	[2]
93	ATTASQAKAVLSAEK	acetylation	[2]
93	ATTASQAKAVLSAEK	succinylation	[2]
100	KAVLSAEKLRDEEVH	acetylation	[2]
100	KAVLSAEKLRDEEVH	succinylation	[2]
159	HYNCEHSKINFRDKR	acetylation	[1]
189	GKLPEVTKDVERTDG	acetylation	[1]
206	LVNAMFFKPHWDEKF	acetylation	[1, 2]
212	FKPHWDEKFHHKMVD	acetylation	[1]
216	WDEKFHHKMVDNRGF	acetylation	[1]
249	YNYYDDEKEKLQMVE	acetylation	[1, 2, 3]
290	LLTKEQLKAWMGKMQ	acetylation	[1, 2]
290	LLTKEQLKAWMGKMQ	succinylation	[2]
295	QLKAWMGKMQKKAVA	acetylation	[1, 2]
295	QLKAWMGKMQKKAVA	succinylation	[2]
299	WMGKMQKKAVAISLP	acetylation	[1, 2]
299	WMGKMQKKAVAISLP	succinylation	[2]
318	EVTHDLQKHLAGLGL	acetylation	[1, 2]
331	GLTEAIDKNKADLSR	acetylation	[1]
379	REELRSPKLFYADHP	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. 

Sequence Annotation

 MOTIF 414 417 Prevents secretion from ER (Probable).
 CARBOHYD 119 119 N-linked (GlcNAc...) (Potential).
 CARBOHYD 124 124 N-linked (GlcNAc...) (Potential).
 CARBOHYD 394 394 N-linked (GlcNAc...) (Potential).  

Keyword

 Chaperone; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Reference proteome; Signal; Stress response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 417 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:Compara.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome.
 GO:0051082; F:unfolded protein binding; IDA:MGI.
 GO:0032964; P:collagen biosynthetic process; IMP:MGI.
 GO:0030199; P:collagen fibril organization; IMP:MGI.
 GO:0051604; P:protein maturation; IMP:MGI.
 GO:0030162; P:regulation of proteolysis; IBA:RefGenome.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 

Interpro

 IPR023795; Protease_inhib_I4_serpin_CS.
 IPR023796; Serpin_dom.
 IPR000215; Serpin_fam. 

Pfam

 PF00079; Serpin 

SMART

 SM00093; SERPIN 

PROSITE

 PS00014; ER_TARGET
 PS00284; SERPIN 

PRINTS