UniProt Accession

 ADR2_HUMAN; Q86V24; Q53YY5; Q9H737 

Genbank Protein ID

 AY424280; AK025085; AK127196; AK128511; CH471116; BC051858 

Genbank Nucleotide ID

 AAR08368.1; BAB15062.1; BAC86881.1; BAC87473.1; EAW88924.1; AAH51858.1 

Protein Name

 Adiponectin receptor protein 2 

Protein Synonyms/Alias

 Progestin and adipoQ receptor family member II 

Gene Name

 ADIPOR2 

Gene Synonyms/Alias

 PAQR2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
97	KMEEFVCKVWEGRWR	ubiquitination	[1, 2]
116	DVLPDWLKDNDFLLH	ubiquitination	[2]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin. 

Sequence Annotation

  

Keyword

 Complete proteome; Fatty acid metabolism; Lipid metabolism; Membrane; Polymorphism; Receptor; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 386 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042562; F:hormone binding; ISS:UniProtKB.
 GO:0004872; F:receptor activity; IEA:Compara.
 GO:0019395; P:fatty acid oxidation; ISS:UniProtKB.
 GO:0009755; P:hormone-mediated signaling pathway; ISS:UniProtKB. 

Interpro

 IPR004254; HlyIII-related. 

Pfam

 PF03006; HlyIII 

SMART

  

PROSITE

  

PRINTS