CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026029
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribonucleoside-diphosphate reductase 
Protein Synonyms/Alias
  
Gene Name
 GK0911 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Geobacillus kaustophilus (strain HTA426) 
NCBI Taxa ID
 235909 
Lysine Modification
Position
Peptide
Type
References
40IIIDDQGKPVSFSREacetylation[1]
221LMVNEPPKRRLELVKacetylation[1]
228KRRLELVKEAYWALSacetylation[1]
441VPAIEVMKSIMRSQLacetylation[1]
497VMKRQYVKDGMIIIEacetylation[1]
Reference
 [1] Proteomic analysis of acetylation in thermophilic Geobacillus kaustophilus.
 Lee DW, Kim D, Lee YJ, Kim JA, Choi JY, Kang S, Pan JG.
 Proteomics. 2013 Aug;13(15):2278-82. [PMID: 23696451] 
Functional Description
 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; DNA replication; Oxidoreductase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 785 AA 
Protein Sequence
MPFFRLSFHP LACPSGFFIE GVGKRMTALT KMIIIDDQGK PVSFSREEFA SLIGQAVAGF 60
GRLSLDEYVE RVWQLLSRKE SVTVEQLHQT AILEGLSYID EDEPDWTFVC ARLYLQQLYR 120
EAARQRGYDA RERYGDFYSL IVSLTEQGVY SPLLLERYTK EEIETAGSFL DPGKDLLFTY 180
IGLRTLADRY LARDYERRLY ELPQERFLVI AMTLMVNEPP KRRLELVKEA YWALSNLYMT 240
VATPTLANAG KSYGQLSSCF VDTVDDSLQG IYDSNTDIAN LSKSGGGIGV YLGKIRSRGS 300
DIKGFKGVSS GVIPWMKQLN NTAVSVDQLG QRKGAISVYL DVWHKDIFAF LDARLNNGDE 360
RLRTHDLFTG VCIPDLFMEQ VEQRGDWYLF DPHEVRKVMG FSLEDFYDEE KGCGSFREKY 420
WQCVNEPRLS KEKVPAIEVM KSIMRSQLES GTPFMFYRDE VNRQNPNRHL GMIYCSNLCT 480
EIAQNQSPTV MKRQYVKDGM IIIEKIPGDF VVCNLSSINL ARAVTDGVLA RLIPIQMRML 540
DNVIDLNNIP VLQAGLTNEK YRAVGLGTFG WHHLLALKGI RWESEEAVRY ADELYETIAY 600
LAIQASMELA KEKGSYPAFP GSDWQTGAYF ERRGYQSHGE LDWDRLKQDV ARYGMRNGYI 660
MAIAPNASTS IIAGSTASID PIFLKVYAEE KKDYKIPVTV PDLNEQTTWY YKSAYHIDQR 720
WSIKQNAARQ RHIDQAISFN FYVMNTIKAK ELLDLHLTAW KSGLKTTYYV RSTSGTIDEC 780
DSCAS 785 
Gene Ontology
 GO:0005971; C:ribonucleoside-diphosphate reductase complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.
 GO:0006260; P:DNA replication; IEA:UniProtKB-UniPathway. 
Interpro
 IPR005144; ATP-cone.
 IPR013346; NrdE_NrdA.
 IPR000788; RNR_lg_C.
 IPR013509; RNR_lsu_N.
 IPR008926; RNR_R1-su_N. 
Pfam
 PF02867; Ribonuc_red_lgC
 PF00317; Ribonuc_red_lgN 
SMART
  
PROSITE
 PS51161; ATP_CONE
 PS00089; RIBORED_LARGE 
PRINTS
 PR01183; RIBORDTASEM1.