UniProt Accession

 PAIP1_HUMAN; Q9H074; A6NKV8; O60455; Q96B61; Q9BS63 

Genbank Protein ID

 AF013758; AL136920; AC114956; BC005295; BC015937; DB089732 

Genbank Nucleotide ID

 AAC39697.2; CAB66854.1; AAH05295.1; AAH15937.1 

Protein Name

 Polyadenylate-binding protein-interacting protein 1 

Protein Synonyms/Alias

 PABP-interacting protein 1; PAIP-1; Poly(A)-binding protein-interacting protein 1 

Gene Name

 PAIP1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
115	NSESAMAKPQVVVAP	ubiquitination	[1]
368	DVKQMLLKLVELRSS	ubiquitination	[1, 2, 3]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

 Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. 

Sequence Annotation

 DOMAIN 159 376 MIF4G.
 REGION 116 143 PABPC1-interacting motif-2 (PAM2).
 REGION 440 479 PABPC1-interacting motif-1 (PAM1).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Reference proteome; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 479 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003723; F:RNA binding; TAS:ProtInc.
 GO:0008494; F:translation activator activity; IDA:UniProtKB.
 GO:0048255; P:mRNA stabilization; TAS:UniProtKB.
 GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; TAS:Reactome.
 GO:0006413; P:translational initiation; TAS:ProtInc. 

Interpro

 IPR016024; ARM-type_fold.
 IPR009818; Ataxin-2_C.
 IPR016021; MIF4-like_typ_1/2/3.
 IPR003890; MIF4G-like_typ-3. 

Pfam

 PF02854; MIF4G
 PF07145; PAM2 

SMART

 SM00543; MIF4G 

PROSITE

  

PRINTS