CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017243
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Shootin-1 
Protein Synonyms/Alias
  
Gene Name
 Kiaa1598 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
89SAEALATKLNKENKTubiquitination[1]
244EMFIEQNKLKRQSHLubiquitination[1]
286ERIQHQKKVKELEERacetylation[2]
288IQHQKKVKELEERLEacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
 Involved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K Activity. Accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons (By similarity). 
Sequence Annotation
 MOD_RES 3 3 Phosphoserine.
 MOD_RES 4 4 Phosphoserine.
 MOD_RES 249 249 Phosphoserine (By similarity).
 MOD_RES 464 464 Phosphoserine.
 MOD_RES 467 467 Phosphoserine.
 MOD_RES 496 496 Phosphothreonine (By similarity).
 MOD_RES 506 506 Phosphoserine (By similarity).
 MOD_RES 515 515 Phosphoserine (By similarity).
 MOD_RES 537 537 Phosphothreonine (By similarity).  
Keyword
 Alternative splicing; Cell projection; Coiled coil; Complete proteome; Developmental protein; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 631 AA 
Protein Sequence
MNSSDEEKQL QLITSLKEQA IGEYEDLRAE NQKTKEKCDK IRQERDEAVK KLEEFQKISH 60
MVIEEVNFMQ NHLEIEKTCR ESAEALATKL NKENKTLKRI SMLYMAKLGP DVITEEINID 120
DDDPATDTDA AAETCVSVQC QKQIKELRDQ IVSVQEEKKV LAIELENLKS KLGEVMEEVN 180
KVKQEKAVLN SEVLEQRKVL EKCNRVSMLA VEEYEELQVN LELEKDLRKK AESFAQEMFI 240
EQNKLKRQSH LLLQSSLPDQ QLLKALDENA KLIQQLEEER IQHQKKVKEL EERLENEALH 300
KEIHNLRQQL ELLEDDKREL EQKYQSSEEK ARNLKHSVDE LQKRVNQSEN SVPPPPPPPP 360
PLPPPPPNPI RSLMSMIRKR SHPSGNSAKK EKTTQPETAE EVTDLKRQAV EEMMDRIKKG 420
VHLRPVNQTA RPKAKPDSLK GSESAVDELK GILGTLNKST SSRSLKSLGP ENSETELERI 480
LRRRKLTAEA DSSSPTGILA TSESKSMPVL GSVSSVTKSA LNKKTLEAEF NNPCPLTPEP 540
GEGPRKLEGC TNPKVTFQPP SKGGYRRKCV GSENQAEPVV VLDPVSTHEP QTKDQAAEKD 600
PTQFEEEGGE TQPEYKEDSG GKTGETDSSN C 631 
Gene Ontology
 GO:0030424; C:axon; IEA:UniProtKB-SubCell.
 GO:0030426; C:growth cone; ISA:MGI.
 GO:0051899; P:membrane depolarization; ISA:MGI.
 GO:0048812; P:neuron projection morphogenesis; IEA:InterPro. 
Interpro
 IPR024849; Shootin-1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS