CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008319
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tubby protein homolog 
Protein Synonyms/Alias
  
Gene Name
 TUB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
407DNGVNPQKASSSTLEubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. 
Sequence Annotation
  
Keyword
 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Membrane; Nucleus; Obesity; Phagocytosis; Reference proteome; Secreted; Sensory transduction. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 506 AA 
Protein Sequence
MGARTPLPSF WVSFFAETGI LFPGGTPWPM GSQHSKQHRK PGPLKRGHRR DRRTTRRKYW 60
KEGREIARVL DDEGRNLRQQ KLDRQRALLE QKQKKKRQEP LMVQANADGR PRSRRARQSE 120
EQAPLVESYL SSSGSTSYQV QEADSLASVQ LGATRPTAPA SAKRTKAAAT AGGQGGAARK 180
EKKGKHKGTS GPAALAEDKS EAQGPVQILT VGQSDHAQDA GETAAGGGER PSGQDLRATM 240
QRKGISSSMS FDEDEEDEEE NSSSSSQLNS NTRPSSATSR KSVREAASAP SPTAPEQPVD 300
VEVQDLEEFA LRPAPQGITI KCRITRDKKG MDRGMYPTYF LHLDREDGKK VFLLAGRKRK 360
KSKTSNYLIS VDPTDLSRGG DSYIGKLRSN LMGTKFTVYD NGVNPQKASS STLESGTLRQ 420
ELAAVCYETN VLGFKGPRKM SVIVPGMNMV HERVSIRPRN EHETLLARWQ NKNTESIIEL 480
QNKTPVWNDD TQSYVLNFHG RVTQASVKNF QIIHGNDPDY IVMQFGRVAE DVFTMDYNYP 540
LCALQAFAIA LSSFDSKLAC E 561 
Gene Ontology
 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0008020; F:G-protein coupled photoreceptor activity; IEA:Compara.
 GO:0044259; P:multicellular organismal macromolecule metabolic process; IEA:Compara.
 GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
 GO:0007602; P:phototransduction; IEA:Compara.
 GO:0050766; P:positive regulation of phagocytosis; IDA:UniProtKB.
 GO:0009725; P:response to hormone stimulus; IEA:Compara.
 GO:0060041; P:retina development in camera-type eye; IEA:Compara.
 GO:0007605; P:sensory perception of sound; IEA:Compara. 
Interpro
 IPR000007; Tubby_C.
 IPR025659; Tubby_C-like.
 IPR018066; Tubby_C_CS.
 IPR005398; Tubby_N. 
Pfam
 PF01167; Tub 
SMART
  
PROSITE
 PS01200; TUB_1
 PS01201; TUB_2 
PRINTS
 PR01573; SUPERTUBBY.
 PR01574; TUBBYPROTEIN.