CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027623
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tyrosine-protein kinase receptor 
Protein Synonyms/Alias
  
Gene Name
 TFG/ALK fusion 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
681KVHGSRNKPTSLWNPubiquitination[1]
697YGSWFTEKPTKKNNPubiquitination[1]
700WFTEKPTKKNNPIAKubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Transferase; Transmembrane; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 803 AA 
Protein Sequence
MNGQLDLSGK LIIKAQLGED IRRIPIHNED ITYDELVLMM QRVFRGKLLS NDEVTIKYKD 60
EDGDLITIFD SSDLSFAIQC SRILKLTLFV NGQPRPLESS QVKYLRRELI ELRNKVNRLL 120
DSLEPPGEPG PSTNIPENDT VDGREEKSAS DSSGKQSTQV MAASMSAFDP LKNQDEINKN 180
VMSAFGLTDD QVSGPPSAPA EDRSGTPDSI ASSSSAAHPP GVQPQQPPYT GAQTQAGQIE 240
VYRRKHQELQ AMQMELQSPE YKLSKLRTST IMTDYNPNYC FAGKTSSISD LKEVPRKNIT 300
LIRGLGHGAF GEVYEGQVSG MPNDPSPLQV AVKTLPEVCS EQDELDFLME ALIISKFNHQ 360
NIVRCIGVSL QSLPRFILLE LMAGGDLKSF LRETRPRPSQ PSSLAMLDLL HVARDIACGC 420
QYLEENHFIH RDIAARNCLL TCPGPGRVAK IGDFGMARDI YRASYYRKGG CAMLPVKWMP 480
PEAFMEGIFT SKTDTWSFGV LLWEIFSLGY MPYPSKSNQE VLEFVTSGGR MDPPKNCPGP 540
VYRIMTQCWQ HQPEDRPNFA IILERIEYCT QDPDVINTAL PIEYGPLVEE EEKVPVRPKD 600
PEGVPPLLVS QQAKREEERS PAAPPPLPTT SSGKAAKKPT AAEVSVRVPR GPAVEGGHVN 660
MAFSQSNPPS ELHKVHGSRN KPTSLWNPTY GSWFTEKPTK KNNPIAKKEP HDRGNLGLEG 720
SCTVPPNVAT GRLPGASLLL EPSSLTANMK EVPLFRLRHF PCGNVNYGYQ QQGLPLEAAT 780
APGAGHYEDT ILKSKNSMNQ PGP 803 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC.
 GO:0000187; P:activation of MAPK activity; IEA:InterPro.
 GO:0048666; P:neuron development; IEA:InterPro.
 GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro. 
Interpro
 IPR026830; ALK.
 IPR011009; Kinase-like_dom.
 IPR000270; OPR_PB1.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR002011; Tyr_kinase_rcpt_2_CS. 
Pfam
 PF00564; PB1
 PF07714; Pkinase_Tyr 
SMART
 SM00666; PB1
 SM00219; TyrKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00239; RECEPTOR_TYR_KIN_II 
PRINTS
 PR00109; TYRKINASE.