UniProt Accession

 ASB1_HUMAN; Q9Y576; A6NL50; Q4ZG29; Q9ULS4 

Genbank Protein ID

 AF156777; AC016999; BC014528; AB032972 

Genbank Nucleotide ID

 AAD41894.1; AAX88934.1; AAH14528.1; BAA86460.1 

Protein Name

 Ankyrin repeat and SOCS box protein 1 

Protein Synonyms/Alias

 ASB-1 

Gene Name

 ASB1 

Gene Synonyms/Alias

 KIAA1146 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
21	GSAGRNLKEWLREQF	ubiquitination	[1]
69	YRSRINEKSVWCCGW	ubiquitination	[1, 2]
161	VGRADILKALIRYGA	ubiquitination	[1]
280	PESRGRRKVDPEALQ	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 

Sequence Annotation

 REPEAT 36 68 ANK 1.
 REPEAT 77 106 ANK 2.
 REPEAT 110 139 ANK 3.
 REPEAT 143 172 ANK 4.
 REPEAT 191 220 ANK 5.
 REPEAT 235 265 ANK 6.
 DOMAIN 286 335 SOCS box.  

Keyword

 ANK repeat; Complete proteome; Developmental protein; Reference proteome; Repeat; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 335 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IC:UniProtKB.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0030539; P:male genitalia development; IEA:Compara.
 GO:0042036; P:negative regulation of cytokine biosynthetic process; NAS:UniProtKB.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. 

Interpro

 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR001496; SOCS_C. 

Pfam

 PF12796; Ank_2
 PF07525; SOCS_box 

SMART

 SM00248; ANK
 SM00969; SOCS_box 

PROSITE

 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50225; SOCS 

PRINTS

 PR01415; ANKYRIN.