UniProt Accession

 TM2D1_HUMAN; Q9BX74; A6NDA8 

Genbank Protein ID

 AF353990; AC099791; BC029486 

Genbank Nucleotide ID

 AAK35064.1; AAH29486.1 

Protein Name

 TM2 domain-containing protein 1 

Protein Synonyms/Alias

 Beta-amyloid-binding protein; hBBP 

Gene Name

 TM2D1 

Gene Synonyms/Alias

 BBP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
59	KVGQYICKDPKINDA	ubiquitination	[1]
109	GNEVGFFKPISCRNV	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May participate in beta-amyloid-induced apoptosis via its interaction with beta-APP42. 

Sequence Annotation

 CARBOHYD 72 72 N-linked (GlcNAc...) (Potential).
 CARBOHYD 87 87 N-linked (GlcNAc...) (Potential).
 CARBOHYD 96 96 N-linked (GlcNAc...) (Potential).  

Keyword

 Apoptosis; Complete proteome; Direct protein sequencing; Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 207 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. 

Interpro

 IPR007829; TM2. 

Pfam

 PF05154; TM2 

SMART

  

PROSITE

  

PRINTS