CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023228
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 
Protein Synonyms/Alias
 hDAPP1; B lymphocyte adapter protein Bam32; B-cell adapter molecule of 32 kDa 
Gene Name
 DAPP1 
Gene Synonyms/Alias
 BAM32; HSPC066 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
182GGLVKTWKTRWFTLHacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K. 
Sequence Annotation
 DOMAIN 35 129 SH2.
 DOMAIN 164 259 PH.
 MOD_RES 139 139 Phosphotyrosine (By similarity).
 MOD_RES 141 141 Phosphoserine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome; SH2 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 280 AA 
Protein Sequence
MGRAELLEGK MSTQDPSDLW SRSDGEAELL QDLGWYHGNL TRHAAEALLL SNGCDGSYLL 60
RDSNETTGLY SLSVRAKDSV KHFHVEYTGY SFKFGFNEFS SLKDFVKHFA NQPLIGSETG 120
TLMVLKHPYP RKVEEPSIYE SVRVHTAMQT GRTEDDLVPT APSLGTKEGY LTKQGGLVKT 180
WKTRWFTLHR NELKYFKDQM SPEPIRILDL TECSAVQFDY SQERVNCFCL VFPFRTFYLC 240
AKTGVEADEW IKILRWKLSQ IRKQLNQGEG TIRSRSFIFK 280 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.
 GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IDA:UniProtKB.
 GO:0004725; F:protein tyrosine phosphatase activity; NAS:UniProtKB.
 GO:0007165; P:signal transduction; TAS:ProtInc. 
Interpro
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR000980; SH2. 
Pfam
 PF00169; PH
 PF00017; SH2 
SMART
 SM00233; PH
 SM00252; SH2 
PROSITE
 PS50003; PH_DOMAIN
 PS50001; SH2 
PRINTS
 PR00401; SH2DOMAIN.