UniProt Accession

 SRO9_YEAST; P25567; D6VQX8 

Genbank Protein ID

 X59720; BK006937 

Genbank Nucleotide ID

 CAA42379.1; DAA07447.1 

Protein Name

 RNA-binding protein SRO9 

Protein Synonyms/Alias

 Suppressor of RHO3 protein 9 

Gene Name

 SRO9 

Gene Synonyms/Alias

 YCL037C; YCL37C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
43	LPTSSPWKLAPTEIP	ubiquitination	[1]
73	KNRTPTPKSSTATKW	ubiquitination	[1]
79	PKSSTATKWVPIKAS	acetylation	[2]
79	PKSSTATKWVPIKAS	ubiquitination	[1]
143	KKQQQMKKDGFESAV	acetylation	[2]
156	AVGEEDSKDATSQEN	ubiquitination	[1, 3]
229	NNNNNRSKYHNHFHH	acetylation	[2]
290	YLRSKLSKDGFAPLS	acetylation	[2]
301	APLSLISKFYRVVNM	ubiquitination	[1, 3]
342	AEGTLAAKEGDNVTG	ubiquitination	[3]
352	DNVTGEAKEPSPLDK	ubiquitination	[1, 3]
419	ASQEQETKEDSAPVA	ubiquitination	[3]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [3] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 May overlap in function with tropomyosin and may be involved in organization of actin filaments. Acts as a multicopy suppressor of RHO3 mutation. RNA-binding protein which may modulate mRNA translation. Involved in heme regulation of HAP1, as a component of the high-molecular-weight complex (HMC). 

Sequence Annotation

 DOMAIN 255 351 HTH La-type RNA-binding.
 MOD_RES 55 55 Phosphoserine.
 MOD_RES 148 148 Phosphoserine.
 MOD_RES 422 422 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 434 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005844; C:polysome; IDA:SGD.
 GO:0003723; F:RNA binding; IDA:SGD.
 GO:0002181; P:cytoplasmic translation; IPI:SGD. 

Interpro

 IPR006630; Lupus_La_RNA-bd.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF05383; La 

SMART

 SM00715; LA 

PROSITE

 PS50961; HTH_LA 

PRINTS