CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043093
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Bone morphogenetic protein 4 
Protein Synonyms/Alias
  
Gene Name
 BMP4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
122INIYEVMKPPAEVVPubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Growth factor; Reference proteome; Secreted. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 271 AA 
Protein Sequence
MFGLRRRPQP SKSAVIPDYM RDLYRLQSGE EEEEQIHSTG LEYPERPASR ANTVRSFHHE 60
EHLENIPGTS ENSAFRFLFN LSSIPENEVI SSAELRLFRE QVDQGPDWER GFHRINIYEV 120
MKPPAEVVPG HLITRLLDTR LVHHNVTRWE TFDVSPAVLR WTREKQPNYG LAIEVTHLHQ 180
TRTHQGQHVR ISRSLPQGSG NWAQLRPLLV TFGHDGRGHA LTRRRRAKRS PKHHSQRARK 240
KNKNCRRHSL YVDFSDVGWN DWIVAPPGYQ A 271 
Gene Ontology
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0008201; F:heparin binding; IEA:Compara.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0009948; P:anterior/posterior axis specification; IEA:Compara.
 GO:0061151; P:BMP signaling pathway involved in renal system segmentation; IEA:Compara.
 GO:0061149; P:BMP signaling pathway involved in ureter morphogenesis; IEA:Compara.
 GO:0060442; P:branching involved in prostate gland morphogenesis; IEA:Compara.
 GO:0060449; P:bud elongation involved in lung branching; IEA:Compara.
 GO:0055007; P:cardiac muscle cell differentiation; IEA:Compara.
 GO:0071363; P:cellular response to growth factor stimulus; IEA:Compara.
 GO:0002062; P:chondrocyte differentiation; IEA:Compara.
 GO:0060197; P:cloacal septation; IEA:Compara.
 GO:0060363; P:cranial suture morphogenesis; IEA:Compara.
 GO:0035993; P:deltoid tuberosity development; IEA:Compara.
 GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Compara.
 GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Compara.
 GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
 GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Compara.
 GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Compara.
 GO:0001958; P:endochondral ossification; IEA:Compara.
 GO:0060684; P:epithelial-mesenchymal cell signaling; IEA:Compara.
 GO:0030218; P:erythrocyte differentiation; IEA:Compara.
 GO:0007281; P:germ cell development; IEA:Compara.
 GO:0072104; P:glomerular capillary formation; IEA:Compara.
 GO:0072015; P:glomerular visceral epithelial cell development; IEA:Compara.
 GO:0060113; P:inner ear receptor cell differentiation; IEA:Compara.
 GO:0060235; P:lens induction in camera-type eye; IEA:Compara.
 GO:0060592; P:mammary gland formation; IEA:Compara.
 GO:0072161; P:mesenchymal cell differentiation involved in kidney development; IEA:Compara.
 GO:0072198; P:mesenchymal cell proliferation involved in ureter development; IEA:Compara.
 GO:0072138; P:mesenchymal cell proliferation involved in ureteric bud development; IEA:Compara.
 GO:0007500; P:mesodermal cell fate determination; IEA:Compara.
 GO:0072205; P:metanephric collecting duct development; IEA:Compara.
 GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Compara.
 GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Compara.
 GO:0010629; P:negative regulation of gene expression; IEA:Compara.
 GO:0060686; P:negative regulation of prostatic bud formation; IEA:Compara.
 GO:0001843; P:neural tube closure; IEA:Compara.
 GO:0048663; P:neuron fate commitment; IEA:Compara.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0001759; P:organ induction; IEA:Compara.
 GO:0021983; P:pituitary gland development; IEA:Compara.
 GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Compara.
 GO:0061047; P:positive regulation of branching involved in lung morphogenesis; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0045603; P:positive regulation of endothelial cell differentiation; IEA:Compara.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Compara.
 GO:0045666; P:positive regulation of neuron differentiation; IEA:Compara.
 GO:0001934; P:positive regulation of protein phosphorylation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IEA:Compara.
 GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0051150; P:regulation of smooth muscle cell differentiation; IEA:Compara.
 GO:0048660; P:regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0003014; P:renal system process; IEA:Compara.
 GO:0010159; P:specification of organ position; IEA:Compara.
 GO:0021978; P:telencephalon regionalization; IEA:Compara.
 GO:0035990; P:tendon cell differentiation; IEA:Compara.
 GO:0060440; P:trachea formation; IEA:Compara.
 GO:0072192; P:ureter epithelial cell differentiation; IEA:Compara.
 GO:0072193; P:ureter smooth muscle cell differentiation; IEA:Compara. 
Interpro
 IPR001839; TGF-b_C.
 IPR001111; TGF-b_N.
 IPR015615; TGF-beta-rel. 
Pfam
 PF00019; TGF_beta
 PF00688; TGFb_propeptide 
SMART
  
PROSITE
 PS51362; TGF_BETA_2 
PRINTS