| Tag | Content |
|---|
| CPLM ID | CPLM-020366 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription factor HES-7 |
Protein Synonyms/Alias | hHes7; Class B basic helix-loop-helix protein 37; bHLHb37; Hairy and enhancer of split 7; bHLH factor Hes7 |
Gene Name | HES7 |
Gene Synonyms/Alias | BHLHB37 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 211 | HRQDGAPKAPLPPPP | ubiquitination | [1] |
|
Reference | [1] Global identification of modular cullin-RING ligase substrates. Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ. Cell. 2011 Oct 14;147(2):459-74. [ PMID: 21963094] |
Functional Description | Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation (By similarity). |
Sequence Annotation | DOMAIN 12 69 bHLH.
DOMAIN 92 122 Orange.
MOTIF 221 224 WRPW motif. |
Keyword | Alternative splicing; Complete proteome; Developmental protein; Disease mutation; DNA-binding; Dwarfism; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 225 AA |
Protein Sequence | MVTRDRAENR DGPKMLKPLV EKRRRDRINR SLEELRLLLL ERTRDQNLRN PKLEKAEILE 60
FAVGYLRERS RVEPPGVPRS PVQDAEALAS CYLSGFRECL LRLAAFAHDA SPAARAQLFS 120
ALHGYLRPKP PRPKPVDPRP PAPRPSLDPA APALGPALHQ RPPVHQGHPS PRCAWSPSLC 180
SPRAGDSGAP APLTGLLPPP PPPHRQDGAP KAPLPPPPAF WRPWP 225 |
Gene Ontology | GO:0005634; C:nucleus; NAS:UniProtKB. GO:0003677; F:DNA binding; NAS:UniProtKB. GO:0008134; F:transcription factor binding; NAS:UniProtKB. GO:0007498; P:mesoderm development; NAS:UniProtKB. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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