| Tag | Content |
|---|
| CPLM ID | CPLM-020177 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nucleoporin NDC1 |
Protein Synonyms/Alias | hNDC1; Transmembrane protein 48 |
Gene Name | NDC1 |
Gene Synonyms/Alias | TMEM48 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 436 | KTSLFSSKLSTPDVV | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. |
Sequence Annotation | MOD_RES 406 406 Phosphoserine.
MOD_RES 414 414 Phosphothreonine.
MOD_RES 439 439 Phosphoserine.
MOD_RES 440 440 Phosphothreonine.
MOD_RES 445 445 Phosphoserine.
MOD_RES 449 449 Phosphothreonine.
MOD_RES 471 471 Phosphoserine.
MOD_RES 474 474 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 674 AA |
Protein Sequence | MATAVSRPCA GRSRDILWRV LGWRIVASIV WSVLFLPICT TVFIIFSRID LFHPIQWLSD 60
SFSDLYSSYV IFYFLLLSVV IIIISIFNVE FYVVPSIPCS RLALIGKIIH PQQLMHSFIH 120
AAMGMVMAWC AAVITQGQYS FLVVPCTGTN SFGSPAAQTC LNEYHLFFLL TGAFMGYSYS 180
LLYFVNNMNY LPFPIIQQYK FLRFRRSLLL LVKHSCVESL FLVRNFCILY YFLGYIPKAW 240
ISTAMNLHID EQVHRPLDTV SGLLNLSLLY HVWLCGVFLL TTWYVSWILF KIYATEAHVF 300
PVQPPFAEGS DECLPKVLNS NPPPIIKYLA LQDLMLLSQY SPSRRQEVFS LSQPGGHPHN 360
WTAISRECLN LLNGMTQKLI LYQEAAATNG RVSSSYPVEP KKLNSPEETA FQTPKSSQMP 420
RPSVPPLVKT SLFSSKLSTP DVVSPFGTPF GSSVMNRMAG IFDVNTCYGS PQSPQLIRRG 480
PRLWTSASDQ QMTEFSNPSP STSISAEGKT MRQPSVIYSW IQNKREQIKN FLSKRVLIMY 540
FFSKHPEASI QAVFSDAQMH IWALEGLSHL VAASFTEDRF GVVQTTLPAI LNTLLTLQEA 600
VDKYFKLPHA SSKPPRISGS LVDTSYKTLR FAFRASLKTA IYRITTTFGE HLNAVQASAE 660
HQKRLQQFLE FKE 673 |
Gene Ontology | GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell. GO:0005643; C:nuclear pore; IDA:UniProtKB. GO:0017056; F:structural constituent of nuclear pore; IMP:UniProtKB. GO:0051028; P:mRNA transport; IEA:UniProtKB-KW. GO:0051292; P:nuclear pore complex assembly; IMP:UniProtKB. GO:0031081; P:nuclear pore distribution; IMP:UniProtKB. GO:0015031; P:protein transport; NAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |