| Tag | Content |
|---|
| CPLM ID | CPLM-008155 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Glutamate dehydrogenase 2, mitochondrial |
Protein Synonyms/Alias | GDH 2 |
Gene Name | GLUD2 |
Gene Synonyms/Alias | GLUDP1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 84 | GASIVEDKLVKDLRT | acetylation | [1] |
|
Reference | [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3. Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C. PLoS One. 2012;7(12):e50545. [ PMID: 23236377] |
Functional Description | Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. |
Sequence Annotation | ACT_SITE 183 183 By similarity.
BINDING 84 84 Substrate (By similarity).
MOD_RES 84 84 N6-acetyllysine (By similarity).
MOD_RES 110 110 N6-acetyllysine (By similarity).
MOD_RES 135 135 Phosphotyrosine (By similarity).
MOD_RES 162 162 N6-acetyllysine (By similarity).
MOD_RES 172 172 ADP-ribosylcysteine.
MOD_RES 183 183 N6-acetyllysine (By similarity).
MOD_RES 191 191 N6-acetyllysine (By similarity).
MOD_RES 363 363 N6-acetyllysine (By similarity).
MOD_RES 365 365 N6-acetyllysine (By similarity).
MOD_RES 386 386 N6-acetyllysine (By similarity).
MOD_RES 399 399 N6-acetyllysine (By similarity).
MOD_RES 415 415 N6-acetyllysine (By similarity).
MOD_RES 450 450 Phosphoserine (By similarity).
MOD_RES 457 457 N6-acetyllysine (By similarity).
MOD_RES 480 480 N6-acetyllysine (By similarity).
MOD_RES 503 503 N6-acetyllysine (By similarity).
MOD_RES 512 512 Phosphotyrosine (By similarity).
MOD_RES 527 527 N6-acetyllysine (By similarity).
MOD_RES 545 545 N6-acetyllysine (By similarity). |
Keyword | Acetylation; ADP-ribosylation; Complete proteome; Mitochondrion; NADP; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 558 AA |
Protein Sequence | MYRYLAKALL PSRAGPAALG SAANHSAALL GRGRGQPAAA SQPGLALAAR RHYSELVADR 60
EDDPNFFKMV EGFFDRGASI VEDKLVKDLR TQESEEQKRN RVRGILRIIK PCNHVLSLSF 120
PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI RYSTDVSVDE VKALASLMTY KCAVVDVPFG 180
GAKAGVKINP KNYTENELEK ITRRFTMELA KKGFIGPGVD VPAPDMNTGE REMSWIADTY 240
ASTIGHYDIN AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SILGMTPGFR 300
DKTFVVQGFG NVGLHSMRYL HRFGAKCIAV GESDGSIWNP DGIDPKELED FKLQHGSILG 360
FPKAKPYEGS ILEVDCDILI PAATEKQLTK SNAPRVKAKI IAEGANGPTT PEADKIFLER 420
NILVIPDLYL NAGGVTVSYF EWLKNLNHVS YGRLTFKYER DSNYHLLLSV QESLERKFGK 480
HGGTIPIVPT AEFQDSISGA SEKDIVHSAL AYTMERSARQ IMHTAMKYNL GLDLRTAAYV 540
NAIEKVFKVY SEAGVTFT 558 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:BHF-UCL. GO:0043531; F:ADP binding; IDA:BHF-UCL. GO:0004352; F:glutamate dehydrogenase (NAD+) activity; IDA:UniProtKB. GO:0004353; F:glutamate dehydrogenase [NAD(P)+] activity; IDA:BHF-UCL. GO:0005525; F:GTP binding; IDA:BHF-UCL. GO:0070728; F:leucine binding; IDA:BHF-UCL. GO:0006537; P:glutamate biosynthetic process; IDA:BHF-UCL. GO:0006538; P:glutamate catabolic process; IDA:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |