CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011318
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CCAAT/enhancer-binding protein beta 
Protein Synonyms/Alias
 C/EBP beta; Transcription factor NF-M; CCR protein 
Gene Name
 CEBPB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Gallus gallus (Chicken) 
NCBI Taxa ID
 9031 
Lysine Modification
Position
Peptide
Type
References
20PIQPPAFKSMEVANFmethylation[1]
119KGSGGGKKPDYTYISmethylation[1]
276RKSRDKAKMRNLETQmethylation[1]
285RNLETQHKVLELTAEmethylation[1]
298AENERLQKKVEQLSRmethylation[1]
299ENERLQKKVEQLSREmethylation[1]
315STLRNLFKQLPEPLLmethylation[1]
Reference
 [1] Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs.
 Leutz A, Pless O, Lappe M, Dittmar G, Kowenz-Leutz E.
 Transcription. 2011 Jan-Feb;2(1):3-8. [PMID: 21326902] 
Functional Description
 Has a role in signal transduction, differentiation and Leukemogenesis of myelomonocytic cells. Binds to the MGF and MIM-1 promoters and activates the transcription of these genes. 
Sequence Annotation
 DOMAIN 254 317 bZIP.
 REGION 258 278 Basic motif (By similarity).
 REGION 280 287 Leucine-zipper (By similarity).  
Keyword
 Activator; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 328 AA 
Protein Sequence
MQRLVAWDAA CLPIQPPAFK SMEVANFYYE ADCLAALNKL HPRAAGGRSM TELTVGDHER 60
AIDFSPYLDP LAASQQPAQP PPPAAAAGGN FEPACSSGGQ DFLSDLFAED YKGSGGGKKP 120
DYTYISLTRH GHPCGSQSHK PGVLPGCFPP QIVETKVEPV FETLDSCKGP RKEEGGAGPG 180
PGGMSSPYGS TVRSYLGYQS VPSGSSGNLS TSSSSSPPGT PNPSESSKSA AGAGGYSGPP 240
AGKNKPKKCV DKHSDEYKLR RERNNIAVRK SRDKAKMRNL ETQHKVLELT AENERLQKKV 300
EQLSRELSTL RNLFKQLPEP LLASSPRC 328 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0050873; P:brown fat cell differentiation; IEA:Compara.
 GO:0071230; P:cellular response to amino acid stimulus; IEA:Compara.
 GO:0001892; P:embryonic placenta development; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0060644; P:mammary gland epithelial cell differentiation; IEA:Compara.
 GO:0033598; P:mammary gland epithelial cell proliferation; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0030182; P:neuron differentiation; IEA:Compara.
 GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Compara.
 GO:0045408; P:regulation of interleukin-6 biosynthetic process; IEA:Compara.
 GO:0034976; P:response to endoplasmic reticulum stress; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara. 
Interpro
 IPR004827; bZIP.
 IPR016468; CCAAT/enhancer-binding. 
Pfam
 PF07716; bZIP_2 
SMART
 SM00338; BRLZ 
PROSITE
 PS50217; BZIP
 PS00036; BZIP_BASIC 
PRINTS