UniProt Accession

 RGS10_HUMAN; O43665; A8K408; B1AMR8; Q6IAZ6; Q96GN0 

Genbank Protein ID

 AF368902; AF045229; AF493934; AK290773; CR457008; AL355273; AC012468; AL355273; CH471066; CH471066; BC009361 

Genbank Nucleotide ID

 AAK52979.1; AAC03783.1; AAM12648.1; BAF83462.1; CAG33289.1; CAI16486.1; CAI16486.1; CAI16488.1; EAW49389.1; EAW49390.1; AAH09361.1 

Protein Name

 Regulator of G-protein signaling 10 

Protein Synonyms/Alias

 RGS10 

Gene Name

 RGS10 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
45	LEDPEGVKRFREFLK	ubiquitination	[1, 2]
140	DSYSRFLKSDLFLKH	ubiquitination	[2, 3]
148	SDLFLKHKRTEEEEE	ubiquitination	[3]
165	PDAQTAAKRASRIYN	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)- alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein. 

Sequence Annotation

 DOMAIN 33 148 RGS.
 LIPID 66 66 S-palmitoyl cysteine.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Lipoprotein; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Signal transduction inhibitor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 173 AA 

Protein Sequence

Gene Ontology

 GO:0043679; C:axon terminus; IEA:Compara.
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0043197; C:dendritic spine; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IBA:RefGenome.
 GO:0005096; F:GTPase activator activity; IBA:RefGenome.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. 

Interpro

 IPR000342; Regulat_G_prot_signal.
 IPR024066; Regulat_G_prot_signal_dom1.
 IPR016137; Regulat_G_prot_signal_superfam. 

Pfam

 PF00615; RGS 

SMART

 SM00315; RGS 

PROSITE

 PS50132; RGS 

PRINTS

 PR01301; RGSPROTEIN.