| Tag | Content |
|---|
| CPLM ID | CPLM-014781 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Junctophilin-4 |
Protein Synonyms/Alias | JP-4; Junctophilin-like 1 protein |
Gene Name | Jph4 |
Gene Synonyms/Alias | Jphl1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 403 | AASSVAEKAVEAARM | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity). |
Sequence Annotation | REPEAT 17 39 MORN 1.
REPEAT 41 62 MORN 2.
REPEAT 63 84 MORN 3.
REPEAT 85 107 MORN 4.
REPEAT 108 130 MORN 5.
REPEAT 131 153 MORN 6.
REPEAT 284 306 MORN 7.
REPEAT 307 329 MORN 8. |
Keyword | Cell membrane; Complete proteome; Endoplasmic reticulum; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 630 AA |
Protein Sequence | MHVPLGRKFD FDDGGCYVGG WEAGRAHGYG VCTGPGAQGE YSGCWAHGFE SLGVFTGPGG 60
HSYQGHWQQG KREGLGVERK SRWTYRGEWL GGLKGRSGVW ESVSGLRYAG LWKDGFQDGY 120
GTETYSDGGT YQGQWQAGKR HGYGVRQSVP YHQAALLRSP RRTSLDSGHS DPPTPPPPLP 180
LPGDEGGSPA SGSRGGFVLA GPGDADGASS RKRTPAAGGF FRRSLLLSGL RAGGRRSSLG 240
SKRGSLRSEV SSEVGSTGPP GSEASGPPIP APPALIEGSA TEVYAGEWRA DRRSGYGVSQ 300
RSNGLRYEGE WLGNRRHGYG RTTRPDGSRE EGKYKRNRLV HGGRVRSLLP LALRRGKVKE 360
KVDRAVEGAR RAVSAARQRQ EIAAARAADA LLKAVAASSV AEKAVEAARM AKLIAQDLQP 420
MLEAPGRRPR QDSGGSDTEP LDEDSPGVYE NGLTPSEGSP ELPSSPASSH QPWRAPPCRS 480
PLPPGGNWGP FSSPKAWPEE WGGPGEQAEE LAGYEAEDEA GMQGPGPRDG SPLLGGCSDS 540
SGSLREEEGE DEESLPQLRA PGGSESEPVT TPVLRGLSSR GPDAGCLTEE FEEPAATERP 600
AQPGAANPLV VGAVALLDLS LAFLFSQLLT 630 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |