CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037001
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Probable E3 ubiquitin-protein ligase HECTD2 
Protein Synonyms/Alias
  
Gene Name
 HECTD2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
53AGLDRGAKGQISTFSubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ligase; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 780 AA 
Protein Sequence
MSEAVRVPSP ATPLVVAAPA PEERKGKESE REKLPPIVSA GAGATAGLDR GAKGQISTFS 60
SFISAVSPKK EAAENRSSPA HLVFPNIKNV REPPPICLDV RQKQRTSMDA SSSEMKAPVL 120
PEPILPIQPK TVKDFQEDVE KVKSSGDWKA VHDFYLTTFD SFPELNAAFK KDATASFNTI 180
EDSGINAKFV NAVYDTLLNT PQDVQKTVLK GIINSLLREW KGPRTKDDLR AYFILLQNPQ 240
FNNTSTYVIY AHLLRQIATL VEADHHFLVH WFKKQYSRLS QKRFKQLVER LLQFISLRLF 300
PAKPEEFPPI TKCSWWIPSA AKVLALLNTA NNLVHPPLIP YTDFYNSTLD HIDLMEEYHT 360
WQNFGNSHRF SFCQYPFVIS VAAKKIIIQR DSEQQMINIA RQSLVDKVSR RQRPDMNILF 420
LNMKVRRTHL VSDSLDELTR KRADLKKKLK VTFVGEAGLD MGGLTKEWFL LLIRQIFHPD 480
YGMFTYHKDS HCHWFSSFKC DNYSEFRLVG ILMGLAVYNS ITLDIRFPPC CYKKLLSPPI 540
IPSDQNIPVG ICNVTVDDLC QIMPELAHGL SELLSHEGNV EEDFYSTFQV FQEEFGIIKS 600
YNLKPGGDKI SVTNQNRKEY VQLYTDFLLN KSIYKQFAAF YYGFHSVCAS NALMLLRPEE 660
VEILVCGSPD LDMHALQRST QYDGYAKTDL TIKYFWDVVL GFPLDLQKKL LHFTTGSDRV 720
PVGGMADLNF KISKNETSTN CLPVAHTCFN QLCLPPYKSK KDLKQKLIIG ISNSEGFGLE 780 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:GOC. 
Interpro
 IPR000569; HECT. 
Pfam
 PF00632; HECT 
SMART
 SM00119; HECTc 
PROSITE
 PS50237; HECT 
PRINTS