UniProt Accession

 MYL6_RAT; Q64119 

Genbank Protein ID

 S77858 

Genbank Nucleotide ID

 AAB34126.1 

Protein Name

 Myosin light polypeptide 6 

Protein Synonyms/Alias

 17 kDa myosin light chain; LC17; Myosin light chain 3; MLC-3; Myosin light chain alkali 3; Myosin light chain A3; Smooth muscle and nonmuscle myosin light chain alkali 6 

Gene Name

 Myl6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
56	LKVLGNPKSDEMNVK	acetylation	[1]
63	KSDEMNVKVLDFEHF	acetylation	[1]
79	PMLQTVAKNKDQGTY	acetylation	[1]
81	LQTVAKNKDQGTYED	acetylation	[1]
81	LQTVAKNKDQGTYED	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Regulatory light chain of myosin. Does not bind calcium. 

Sequence Annotation

 DOMAIN 7 42 EF-hand 1.
 DOMAIN 84 119 EF-hand 2.
 DOMAIN 119 151 EF-hand 3.
 MOD_RES 2 2 N-acetylcysteine (By similarity).
 MOD_RES 81 81 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Motor protein; Muscle protein; Myosin; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 151 AA 

Protein Sequence

Gene Ontology

 GO:0016461; C:unconventional myosin complex; TAS:BHF-UCL.
 GO:0030898; F:actin-dependent ATPase activity; ISS:HGNC.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0003774; F:motor activity; TAS:HGNC.
 GO:0008307; F:structural constituent of muscle; ISS:HGNC.
 GO:0030049; P:muscle filament sliding; TAS:HGNC.
 GO:0007519; P:skeletal muscle tissue development; TAS:HGNC. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom. 

Pfam

 PF13405; EF_hand_4
 PF13499; EF_hand_5 

SMART

 SM00054; EFh 

PROSITE

 PS50222; EF_HAND_2 

PRINTS