CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035516
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Laminin, alpha 1 
Protein Synonyms/Alias
 Protein Lama1 
Gene Name
 Lama1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1750RFQKPQEKLKALKEAacetylation[1]
1752QKPQEKLKALKEASSacetylation[1]
2804PALLSDGKWHTVKTEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Laminin EGF-like domain; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3083 AA 
Protein Sequence
MRGSGTGVAL LVLLASVLWV TVRSQQRGLF PAILNLATNA HISANATCGE KGPEMFCKLV 60
EHVPGRPVRH AQCRVCDGNS TNPRERHPIT HAIDGTNNWW QSPSIQNGRE YHWVTVTLDL 120
RQVFQVAYVI IKAANAPRPG NWILERSVDG VKFRPWQYYA VSDTECLTRY KITPRRGPPT 180
YRADNEVICT SYYSKLVPLE HGEIHTSLIN GRPSADDPSP QLLEFTSARY IRLRLQRIRT 240
LNADLMTLSH RDLRDLDPIV TRRYYYSIKD ISVGGMCICS GHASSCPWDE EAKQLQCQCE 300
HNTCGESCDR CCPGFHQQPW RPGTISSSNQ CEECNCHNKA KDCYYDNNVA KERKSLNTAG 360
QYSGGGVCIN CLQNTTGINC ETCIDQYYRP HKVSPYEDQP CRPCDCDPVG SLSSVCIKDD 420
LHADLANGKW PGQCPCRKGY AGDKCDRCQF GYRGFPNCVP CDCSTVGSVN EDPCTEPCLC 480
KKNVEGENCD RCKPGFYNLK ERNPEGCSEC FCFGVSDVCD SLTWSVSQVT NMSGWLVTDL 540
ISPNKIRSQQ DALGRHRQIS INNTAVMHRF TSPYYWAAPE AYLGNKLTAF GGFLKYTVSY 600
DIPVETVDSN LMSHADVIIK GNGLTISTRA EGLSLQPYEE YFNVVRLVPE NFRDFNTRRE 660
IDRDQLMTVL ANVTHLLIRA NYNSAKMALY RLDSVSLDIA SPNAIDLVVA ADVEHCECPQ 720
GYTGTSCEAC LPGYYRVDGI LFGGICQPCE CHGHSSECDI HGICSGCTHN TTGDHCEQCL 780
PGFYGTPSRG TPGDCQPCAC PLSIDSNNFS PTCHLTDREE VVCDQCAPGY SGAWCERCAD 840
GYYGNPTVPG GTCVPCNCSG NVDPLEAGHC DSVTGECLKC LWNTDGAHCE RCADGFYGDA 900
VTAKNCRACN CHENGSLSGI CHLETGLCDC KPYVTGQQCD QCLPGYYGLD TGLGCVPCNC 960
SGEGSISDNC TEEGQCHCVP GVSGKQCDQC SHGFYAFQNG GCTPCDCAHT QNNCDPDSGE 1020
CLCPPHTHGL KCEQCEEAFW GLDPEQGCQA CNCSVVGSTS PQCDVLSGQC SCKEGFGGQS 1080
CHQCSLGYRS FPDCVPCDCD LRGTLADTCD LEQGLCSCTE DSGTCSCKEN VLGPQCDKCR 1140
AGTFALRADN PLGCSPCFCF GLSQLCSELE GYVRAPITLA SDQPILHVVS QSNLKGTTEG 1200
VHFQPPDTLL DAEAVRQHIY AEPFYWRLPK QFQGDQLLAY GGKLQYTVAF YSTLGTGTSN 1260
YEPQVLIKGG RTRKHIIYMD APAPENGVRQ DYEVGMKEEF WKYFNSVSEK HVTHSDFMSV 1320
LSNIEYILIK ASYGQGLQQS RIANISMEVG RKAVEPAPEG KVALQLELCV CPPGTAGHSC 1380
QDCAPGYHRG KLPESSGRGP RPLLAPCVPC NCNNHSDVCD PETGKCLNCR DHTAGDHCEL 1440
CTAGYYGKVI GLPGDCTPCT CPHHPPFSFS PTCVLEGDSG FWCDACLPGY EGQYCERCSA 1500
GYHGNPRAAG GSCQKCDCNP QGSVHSDCDR ASGQCVCKPG ATGLHCEECL PRHILMESHC 1560
VSCDDECVGA LLNDLDSIGD AVLSLNLAGV SLAPYGTLEN LENTTKYFQG YLLEENAKKV 1620
QAEIQLGGIE EQTENLQKEL ARVLRSHQQV NTAMERTSNR SQALATFLEQ LHRNIKEITE 1680
KVATLNQTTG EDFQPPVSAL QSLHQNISSL LALIKKRNFT EMRQNATLEL KAAKDLLSRI 1740
QKRFQKPQEK LKALKEASSL LSNHIADLQA AEELLREAGS KTQESSLLLL LVKANLKDFR 1800
EKKLHVQEEQ NLTSKLIAQG REWVDAARTH AAAAQDTLTQ LEHHRDELLL WASKIRSHVD 1860
DLVMQMSKRR ARDLVHRAEQ HASELQSAAE ALDRDLENVR NVSLNATSAV HVHTNIQTLT 1920
EEAESLAADA HKTANKTSLI SESLAPRGKA VLQRSSRFVK ESVSTRKKQQ GITLKLDELK 1980
NLTSQFQERV DNITRQANDS LTVLRESPGG MREKSRKVKE LAVAANETAA RTLEDMLGLS 2040
LRVFNTSEDL SRVNATVQET KDLLHNSTMT TILAGRKMRD MEMQANLLFD RLKPLKMLEE 2100
NLSRNLSEIK LLISRARKQA ASIKVAVSAD RDCIRAYQPQ ISSTNYNTLL LNVKTQEPDN 2160
LLFYLGSSSS SDFLAVEMRR GKAAFLWDLG SGSTRLEFPD VSINNDKWHS IYITRFGNMG 2220
SLSVKEASAA EDPPVRTSKS PGLANVLDIN NSTLMFVGGL GGQIKKSPAV KVTHFKGCMG 2280
EAFLNGKSIG LWNYIEREGK CNGCFGSSQN EDASFHFDGS GYAVVEKALR PTVTQIIILF 2340
STFSPNGLLF YLASNGTKDF LSIELLRGRV KVMVDLGSGP LTLMTDRRYN NGTWYKIAFQ 2400
RNRKQGLLAV FDAYDTSDKE TKQGETPGAA SDLNRLEKDL IYVGGLPHSK AVRKGVSSRS 2460
YVGCIKNLEI SRSTFDLLRN SYGVRKGCTL EPIQSVSFLK GGYMEMPPKS LSPESSLLAT 2520
FATKNSSGVI LAALGKDAEK AGASQAHVPF FSILLIEGRI EVHINSGDGT SLRKALLHAP 2580
TGSYSDGQEH SISVVRNRRV ITVQLDENSP VEMKLGPLTE GRTINISNLY IGGLPEGKGT 2640
PMIRMRTSFH GCIKNVVIDA QLLDFTRAAG SEQVELDTCL LAEEPTQGLH REHGELPPEP 2700
PTLPEPELCA VDTAPGYVAG AHQFGLSQNS HLVLPFNQSD VRKRLQVQLN IRTFASSGLI 2760
YYVAHQNQMD YAVLQLHEGR LNFMFDLGKG RTKVSHPALL SDGKWHTVKT EYIKRKAFMT 2820
VDGQESPSVT VVGNATTLDV ERKLYLGGLP AHYRARSIGT ITHSIPACIG DVTVNSQQLD 2880
KDRPASAFAV DRCYAVAQEG TFFEGSGYAA LVKEGYKVRL DLNITLEFRT SSKNGVLLGI 2940
SSAKVDAIGL EIVDGKVSFH VNNGAGRITA TYKPRATRTL CDGKWHTLHA HKSRHRIVLT 3000
VDGDAVRAES PHTHSTSADT NDPIYVGGYP AHVKQNCLSS RASFRGCVRN LELSRGSQVQ 3060
SLDLSRAFDL HGVFPHSCPG PEP 3083 
Gene Ontology
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005606; C:laminin-1 complex; IEA:Compara.
 GO:0005608; C:laminin-3 complex; IEA:Compara.
 GO:0005201; F:extracellular matrix structural constituent; IEA:Compara.
 GO:0043208; F:glycosphingolipid binding; IEA:Compara.
 GO:0060445; P:branching involved in salivary gland morphogenesis; IEA:Compara.
 GO:0007155; P:cell adhesion; IEA:InterPro.
 GO:0007166; P:cell surface receptor signaling pathway; IEA:Compara.
 GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IEA:Compara.
 GO:0045198; P:establishment of epithelial cell apical/basal polarity; IEA:Compara.
 GO:0002011; P:morphogenesis of an epithelial sheet; IEA:Compara.
 GO:0031175; P:neuron projection development; IEA:Compara.
 GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
 GO:0030334; P:regulation of cell migration; IEA:InterPro.
 GO:0045995; P:regulation of embryonic development; IEA:InterPro.
 GO:0061304; P:retinal blood vessel morphogenesis; IEA:Compara. 
Interpro
 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp.
 IPR013032; EGF-like_CS.
 IPR002049; EGF_laminin.
 IPR018031; Laminin_B_subgr.
 IPR000034; Laminin_B_type_IV.
 IPR001791; Laminin_G.
 IPR009254; Laminin_I.
 IPR010307; Laminin_II.
 IPR008211; Laminin_N. 
Pfam
 PF00052; Laminin_B
 PF00053; Laminin_EGF
 PF00054; Laminin_G_1
 PF02210; Laminin_G_2
 PF06008; Laminin_I
 PF06009; Laminin_II
 PF00055; Laminin_N 
SMART
 SM00180; EGF_Lam
 SM00281; LamB
 SM00282; LamG
 SM00136; LamNT 
PROSITE
 PS00022; EGF_1
 PS01248; EGF_LAM_1
 PS50027; EGF_LAM_2
 PS50025; LAM_G_DOMAIN
 PS51115; LAMININ_IVA
 PS51117; LAMININ_NTER 
PRINTS