UniProt Accession

 NEUM_MOUSE; P06837 

Genbank Protein ID

 J02809; BC028288; BC080758 

Genbank Nucleotide ID

 AAA37377.1; AAH28288.1; AAH80758.1 

Protein Name

 Neuromodulin 

Protein Synonyms/Alias

 Axonal membrane protein GAP-43; Calmodulin-binding protein P-57; Growth-associated protein 43 

Gene Name

 Gap43 

Gene Synonyms/Alias

 Basp2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
19	EKNDEDQKIEQDGVK	ubiquitination	[1]
37	KAHKAATKIQASFRG	ubiquitination	[1]
56	KKLKGEKKGDAPAAE	ubiquitination	[1]
67	PAAEAEAKEKDDAPV	ubiquitination	[1]
69	AEAEAKEKDDAPVAD	ubiquitination	[1]
80	PVADGVEKKEGDGSA	ubiquitination	[1]
81	VADGVEKKEGDGSAT	ubiquitination	[1]
104	PKAEEPSKAGDAPSE	ubiquitination	[1]
125	DAAPSEEKAGSAETE	ubiquitination	[1]
136	AETESAAKATTDNSP	ubiquitination	[1]
199	SSQAEEEKDAVDEAK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. 

Sequence Annotation

 DOMAIN 31 60 IQ.
 REGION 1 4 Important for membrane binding.
 MOD_RES 41 41 Phosphoserine; by PHK (Probable).
 MOD_RES 95 95 Phosphothreonine.
 MOD_RES 96 96 Phosphoserine.
 MOD_RES 103 103 Phosphoserine.
 MOD_RES 172 172 Phosphothreonine.
 MOD_RES 192 192 Phosphoserine; by CK2 (By similarity).
 MOD_RES 193 193 Phosphoserine; by CK2 (By similarity).
 LIPID 3 3 S-palmitoyl cysteine (By similarity).
 LIPID 4 4 S-palmitoyl cysteine (By similarity).  

Keyword

 3D-structure; Calmodulin-binding; Cell junction; Cell membrane; Cell projection; Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; Growth regulation; Lipoprotein; Membrane; Neurogenesis; Palmitate; Phosphoprotein; Reference proteome; Synapse. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 227 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IDA:MGI.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0031527; C:filopodium membrane; IEA:UniProtKB-SubCell.
 GO:0032584; C:growth cone membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
 GO:0016198; P:axon choice point recognition; IMP:MGI.
 GO:0045165; P:cell fate commitment; IMP:MGI.
 GO:0010001; P:glial cell differentiation; IMP:MGI.
 GO:0051489; P:regulation of filopodium assembly; IEA:Compara.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
 GO:0042246; P:tissue regeneration; IEA:Compara. 

Interpro

 IPR000048; IQ_motif_EF-hand-BS.
 IPR001422; Neuromodulin.
 IPR017454; Neuromodulin_C.
 IPR018947; Neuromodulin_gap-junction_N.
 IPR018243; Neuromodulin_palmitoyl/P_site. 

Pfam

 PF00612; IQ
 PF06614; Neuromodulin
 PF10580; Neuromodulin_N 

SMART

 SM00015; IQ 

PROSITE

 PS50096; IQ
 PS00412; NEUROMODULIN_1
 PS00413; NEUROMODULIN_2 

PRINTS

 PR00215; NEUROMODULIN.