UniProt Accession

 MAEA_MOUSE; Q4VC33; Q3TFH0; Q3U7T6; Q5XKE6; Q8BPI3; Q8BSA1; Q9JK49 

Genbank Protein ID

 AK034859; AK075637; AK145800; AK152523; AK169149; BC039054; BC058687; AF263247 

Genbank Nucleotide ID

 BAC28857.1; BAC35873.1; BAE26657.1; BAE31283.1; BAE40928.1; AAH39054.1; AAH58687.1; AAF72195.1 

Protein Name

 Macrophage erythroblast attacher 

Protein Synonyms/Alias

 Erythroblast macrophage protein 

Gene Name

 Maea 

Gene Synonyms/Alias

 Emp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
31	VPYETLNKRFRAAQK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events. 

Sequence Annotation

 DOMAIN 121 153 LisH.
 DOMAIN 159 216 CTLH.
 REGION 1 124 Extracellular and involved in cell to  

Keyword

 Actin-binding; Alternative splicing; Cell cycle; Cell division; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Erythrocyte maturation; Membrane; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 396 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IDA:MGI.
 GO:0005826; C:actomyosin contractile ring; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
 GO:0005819; C:spindle; IEA:Compara.
 GO:0003779; F:actin binding; IDA:MGI.
 GO:0007155; P:cell adhesion; IEA:Compara.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007010; P:cytoskeleton organization; IMP:MGI.
 GO:0048822; P:enucleate erythrocyte development; IMP:MGI.
 GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW.
 GO:0033033; P:negative regulation of myeloid cell apoptotic process; IEA:Compara. 

Interpro

 IPR013144; CRA_dom.
 IPR024964; CTLH/CRA.
 IPR006595; CTLH_C.
 IPR006594; LisH_dimerisation.
 IPR027370; zf-RING_LisH. 

Pfam

 PF10607; CLTH
 PF13445; zf-RING_LisH 

SMART

 SM00757; CRA
 SM00668; CTLH
 SM00667; LisH 

PROSITE

 PS50897; CTLH
 PS50896; LISH 

PRINTS