UniProt Accession

 CREM_HUMAN; Q03060; A8K014; A8K3J7; A8K6A1; A8MPQ2; B4DXC1; C9J785; C9JZ10; E9PAR4; E9PHM1; O75519; Q14501; Q14503; Q14504; Q14505; Q14506; Q15731; Q16114; Q16116; Q5T9H7; Q5W1A6; Q5W1A7; Q5W1A8; Q5W1A9; Q5W1B0; Q5W1B2; Q7Z2Q6; Q8IVD4; Q96AG7; Q9NZ98; Q9NZ99; Q9NZB9 

Genbank Protein ID

 D14825; D14826; D14826; D14826; D14826; U44836; AF069065; AY292864; AK289379; AK290612; AK291566; AK301906; AL117336; AL157783; CH471072; CH471072; BC017117; BC066342; BC090051; AF213899; AF212158; AF213897; AF213898; AF417234; S68271; S68134; Z15159; AF217318; AF214665; AF217318; AF214665 

Genbank Nucleotide ID

 BAA03562.1; BAA03564.1; BAA03565.1; BAA03566.1; BAA03567.1; AAB03751.1; AAC19383.1; AAP44115.1; BAF82068.1; BAF83301.1; BAF84255.1; BAG63333.1; EAW85917.1; EAW85918.1; AAH17117.1; AAH66342.1; AAH90051.1; AAF68266.2; AAF68266.2; AAF68266.2; AAF68266.2; AAN32656.1; AAC60616.2; AAC60617.2; CAA78858.1; AAF66158.2; AAF66158.2; AAF68682.1; AAF68682.1 

Protein Name

 cAMP-responsive element modulator 

Protein Synonyms/Alias

 Inducible cAMP early repressor; ICER 

Gene Name

 CREM 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
330	AVLENQNKTLIEELK	ubiquitination	[1]
337	KTLIEELKALKDLYC	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (By similarity). 

Sequence Annotation

 DOMAIN 104 163 KID.
 DOMAIN 302 361 bZIP.
 REGION 303 328 Basic motif (By similarity).
 REGION 330 351 Leucine-zipper (By similarity).
 MOD_RES 287 287 Phosphoserine.
 MOD_RES 290 290 Phosphoserine.
 MOD_RES 293 293 Phosphoserine.  

Keyword

 Activator; Alternative promoter usage; Alternative splicing; Complete proteome; Developmental protein; Differentiation; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Spermatogenesis; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 361 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0008140; F:cAMP response element binding protein binding; NAS:UniProtKB.
 GO:0003677; F:DNA binding; NAS:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0006687; P:glycosphingolipid metabolic process; IEA:Compara.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0007165; P:signal transduction; TAS:ProtInc.
 GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR004827; bZIP.
 IPR003102; Coactivator_CBP_pKID.
 IPR001630; Leuzip_CREB. 

Pfam

 PF00170; bZIP_1
 PF02173; pKID 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC
 PS50953; KID 

PRINTS

 PR00041; LEUZIPPRCREB.