UniProt Accession

 SDS3_YEAST; P40505; D6VVK2 

Genbank Protein ID

 U62525; Z46728; AY692879; BK006942 

Genbank Nucleotide ID

 AAB40993.1; CAA86710.1; AAT92898.1; DAA08468.1 

Protein Name

 Transcriptional regulatory protein SDS3 

Protein Synonyms/Alias

 Suppressor of defective silencing protein 3 

Gene Name

 SDS3 

Gene Synonyms/Alias

 YIL084C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
9	AIQKVSNKDLSRKDK	acetylation	[1]
27	NIESKVNKIYQNFYS	acetylation	[1]
124	LYSSIEQKIKKLQEE	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. SDS3 is required for the HDAC activity of the complex and for the RPD3-SIN3 association. 

Sequence Annotation

 MOD_RES 166 166 Phosphoserine.
 MOD_RES 211 211 Phosphoserine.  

Keyword

 Chromatin regulator; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0033698; C:Rpd3L complex; IDA:SGD.
 GO:0070210; C:Rpd3L-Expanded complex; IDA:SGD.
 GO:0006342; P:chromatin silencing; IGI:SGD.
 GO:0016575; P:histone deacetylation; IMP:SGD.
 GO:0061188; P:negative regulation of chromatin silencing at rDNA; IMP:SGD.
 GO:0061186; P:negative regulation of chromatin silencing at silent mating-type cassette; IMP:SGD.
 GO:0031939; P:negative regulation of chromatin silencing at telomere; IMP:SGD.
 GO:0061408; P:positive regulation of transcription from RNA polymerase II promoter in response to heat stress; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR013907; Sds3. 

Pfam

 PF08598; Sds3 

SMART

  

PROSITE

  

PRINTS