CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041710
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cadherin EGF LAG seven-pass G-type receptor 2 
Protein Synonyms/Alias
 RCG28504 
Gene Name
 Celsr2 
Gene Synonyms/Alias
 rCG_28504 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
2034SVTFSELKGFAERLQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Cell membrane; Complete proteome; Disulfide bond; EGF-like domain; G-protein coupled receptor; Membrane; Receptor; Reference proteome; Repeat; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2919 AA 
Protein Sequence
MRSRAASAPL PTPLLPLLLL LLLLPPSPLL GDQVGPCRSL GSGGRGSSGA CAPVGWLCPA 60
SASNLWLYTS RCRDSGIELT GHLVPHHDGL RVWCPESGAH IPLPPSSEGC PWSCRLLGIG 120
GHLSPQGTLT LPQEHPCLKA PRLRCQSCKL AQAPGLRAGE GSREESMGGR RKRNVNTAPQ 180
FQPPSYQATV PENQPAGTSV ASLRAIDPDE GEAGRLEYTM DALFDSRSNH FFSLDPITGA 240
VTTAEELDRE TKSTHVFRVT AQDHGMPRRS ALATLTILVT DTNDHDPVFE QQEYKESLRE 300
NLEVGYEVLT VRATDGDAPP NANILYRLLE GPGGSPSEVF EIDPRSGVIR TRGPVDREEV 360
ESYKLIVEAS DQGRDPGPRS STAVVFLSVE DDNDNAPQFS EKRYVVQVRE DVTPGAPVLR 420
VTASDRDKGS NALVHYSIMS GNARGQFYLD AQTGALDVVS PLDYETTKEY TLRIRAQDGG 480
RPPLSNVSGL VTVQVLDIND NAPIFVSTPF QATVLESVPL GYLVLHVQAI DADAGENARL 540
EYSLAGVGHD FPFTINNGTG WISVAAELDR EEVDFYSFGV EARDHGTPAL TASASVSVTI 600
LDVNDNNPTF TQPEYTVRLN EDAAVGTSVV TVSAVDRDAH SVITYQITSG NTRNRFSITS 660
QSGGGLVSLA LPLDYKLERQ YVLAVTASDG TRQDTAQIVV NVTDANTHRP VFQSSHYTVN 720
VNEDRPAGTT VVLISATDED TGENARITYF MEDSIPQFRI DADTGAVTTQ AELDYEDQVS 780
YTLAITARDN GIPQKSDTTY LEILVNDVND NAPQFLRDSY QGSVYEDVPP FTSVLQISAT 840
DRDSGLNGRV FYTFQGGDDG DGDFIVESTS GIVRTLRRLD RENVAQYILR AYAVDKGMPP 900
ARTPMEVTVT VLDVNDNPPV FEQDEFDVFV EENSPIGLAV ARVTATDPDE GTNAQIMYQI 960
VEGNIPEVFQ LDIFSGELTA LVDLDYEDRP EYILVIQATS APLVSRATVH VRLLDRNDNP 1020
PVLGNFEILF NNYVTNRSSS FPGGAIGRVP AHDPDISDSL TYSFERGNEL SLVLLNASTG 1080
ELRLSRALDN NRPLEAIMSV LVSDGVHSVT AQCSLRVTII TDEMLTHSIT LRLEDMSPER 1140
FLSPLLGLFI QAVAATLATP PDHVVVFNVQ RDTDAPGGHI LNVSLSVGQP PGPGGGPPFL 1200
PSEDLQERLY LNRSLLTAIS AQRVLPFDDN ICLREPCENY MRCVSVLRFD SSAPFIASSS 1260
VLFRPIHPVG GLRCRCPPGF TGDYCETEVD LCYSRPCGPH GHCRSREGGY TCLCRDGYTG 1320
EHCEVSARSG RCTPGVCKNG GTCVNLLVGG FKCDCPSGDF EKPFCQVTTR SFPARSFITF 1380
RGLRQRFHFT LALSFATKER DGLLLYNGRF NEKHDFVALE VIQEQVQLTF SAGESTTTVS 1440
PFVPGGVSDG QWHTVQLKYY NKPLLGQTGL PQGPSEQKVA VVSVDGCDTG VALRFGAMLG 1500
NYSCAAQGTQ GGSKKSLDLT GPLLLGGVPD LPESFPVRMR HFVGCMKNLQ VDSRHVDMAD 1560
FIANNGTVPG CPTKKNVCDS NTCHNGGTCV NQWDAFSCEC PLGFGGKSCA QEMANPQRFL 1620
GSSLVAWHGL SLPISQPWHL SLMFRTRQAD GVLLQAVTRG RSTITLQLRA GHVVLSVEGT 1680
GLQASSLRLE PGRANDGDWH HAQLSLGASG GPGHAILSFD YGQQKAEGNL GPRLHGLHLS 1740
NMTVGGVPGP ASSVARGFRG CLQGVRVSET PEGVSSLDPS RGESINVEPG CSWPDPCDSN 1800
PCPTNSYCSN DWDSYSCSCD PGYYGDNCTN VCDLNPCEHQ SVCTRKPSAP HGYICECLPN 1860
YLGPYCETRI DQPCPRGWWG HPTCGPCNCD VSKGFDPDCN KTSGECHCKE NHYRPPSSPT 1920
CLLCDCYPTG SLSRVCDPED GQCPCKPGVI GRQCDRCDNP FAEVTTNGCE VNYDSCPRAI 1980
EAGIWWPRTR FGLPAAAPCP KGSFGTAVRH CDEHRGWLPP NLFNCTSVTF SELKGFAERL 2040
QRNESGLDSG RSQRLALLLR NATQHTSGYF GSDVKVAYQL ATRLLAHESA QRGFGLSATQ 2100
DVHFTENLLR VGSALLDAAN KRHWELIQQT EGGTAWLLQH YEAYASALAQ NMRHTYLSPF 2160
TIVTPNIVIS VVRLDKGNFA GTKLPRYEAL RGERPPDLET TVILPESVFR EMPPMVRSAG 2220
PGEAQETEEL ARRQRRHPEL SQGEAVASVI IYHTLAGLLP HNYDPDKRSL RVPKRPVINT 2280
PVVSISVHDD EELLPRALDK PVTVQFRLLE TEERTKPICV FWNHSILVSG TGGWSARGCE 2340
VVFRNESHVS CQCNHMTSFA VLMDVSRREN GEILPLKTLT YVALGVTLAA LMITFLFLTL 2400
LRALRSNQHG IRRNLTAALG LAQLVFLLGI NQADLPFACT VIAILLHFLY LCTFSWALLE 2460
ALHLYRALTE VRDVNASPMR FYYMLGWGVP AFITGLAVGL DPEGYGNPDF CWLSIYDTLI 2520
WSFAGPVAFA VSMSVFLYIL SARASCAAQR QGFEKKGPVS GLRSSFTVLL LLSATWLLAL 2580
LSVNSDTLLF HYLFAACNCV QGPFIFLSYV VLSKEVRKAL KFACSRKPSP DPALTTKSTL 2640
TSSYNCPSPY ADGRLYQPYG DSAGSLHSAS RSGKSQPSYI PFLLREESTL NPGQVPPGLG 2700
DPSGLFMEGQ AQQHDPDTDS DSDLSLEDDQ SGSYASTHSS DSEEEEEEAA FPGEQGWDSL 2760
LGPGAERLPL HSTPKDGGPG SGKVPWPGDF GTTTKENSGS GPLEERPREN GDALTREGSL 2820
GPLPGPSTQP HKGILKKKCL PTISEKSSLL RLPLEQGTGS SRGSTASEGS RNGPPPRPPP 2880
RQSLQEQLNG VMPIAMSIKA GTVDEDSSGS EFLFFNFLH 2919 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
 GO:0007156; P:homophilic cell adhesion; IEA:InterPro.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
 GO:0021591; P:ventricular system development; IEA:Compara. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR020894; Cadherin_CS.
 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp.
 IPR022624; DUF3497.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR002049; EGF_laminin.
 IPR017981; GPCR_2-like.
 IPR001879; GPCR_2_extracellular_dom.
 IPR000832; GPCR_2_secretin-like.
 IPR000203; GPS_dom.
 IPR001791; Laminin_G.
 IPR001368; TNFR/NGFR_Cys_rich_reg. 
Pfam
 PF00002; 7tm_2
 PF00028; Cadherin
 PF12003; DUF3497
 PF00008; EGF
 PF01825; GPS
 PF00053; Laminin_EGF
 PF02210; Laminin_G_2 
SMART
 SM00112; CA
 SM00181; EGF
 SM00179; EGF_CA
 SM00180; EGF_Lam
 SM00303; GPS
 SM00008; HormR
 SM00282; LamG
 SM00208; TNFR 
PROSITE
 PS00010; ASX_HYDROXYL
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01248; EGF_LAM_1
 PS50027; EGF_LAM_2
 PS50227; G_PROTEIN_RECEP_F2_3
 PS50261; G_PROTEIN_RECEP_F2_4
 PS50221; GPS
 PS50025; LAM_G_DOMAIN 
PRINTS
 PR00205; CADHERIN.
 PR00249; GPCRSECRETIN.