| Tag | Content |
|---|
| CPLM ID | CPLM-023720 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquitin-conjugating enzyme E2 D4 |
Protein Synonyms/Alias | HBUCE1; Ubiquitin carrier protein D4; Ubiquitin-protein ligase D4 |
Gene Name | UBE2D4 |
Gene Synonyms/Alias | UBCH5D |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 144 | LAREWTQKYAM**** | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination. |
Sequence Annotation | ACT_SITE 85 85 Glycyl thioester intermediate (By |
Keyword | ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Reference proteome; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 147 AA |
Protein Sequence | MALKRIQKEL TDLQRDPPAQ CSAGPVGDDL FHWQATIMGP NDSPYQGGVF FLTIHFPTDY 60
PFKPPKVAFT TKIYHPNINS NGSICLDILR SQWSPALTVS KVLLSICSLL CDPNPDDPLV 120
PEIAHTYKAD REKYNRLARE WTQKYAM 147 |
Gene Ontology | GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB. GO:0044314; P:protein K27-linked ubiquitination; IDA:UniProtKB. GO:0035519; P:protein K29-linked ubiquitination; IDA:UniProtKB. GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB. GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB. GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB. |
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SMART | |
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PRINTS | |