| Tag | Content |
|---|
| CPLM ID | CPLM-000066 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Importin-5 |
Protein Synonyms/Alias | Imp5; Importin subunit beta-3; Karyopherin beta-3; Ran-binding protein 5; RanBP5 |
Gene Name | IPO5 |
Gene Synonyms/Alias | KPNB3; RANBP5 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 47 | ETQSSMRKKVCDIAA | ubiquitination | [1] | | 48 | TQSSMRKKVCDIAAE | ubiquitination | [1] | | 74 | NQWPEGLKFLFDSVS | ubiquitination | [1] | | 611 | DQQSFGIKTAGLEEK | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. |
Sequence Annotation | DOMAIN 28 99 Importin N-terminal.
REPEAT 212 249 HEAT 1.
REPEAT 395 432 HEAT 2.
REPEAT 437 475 HEAT 3.
REPEAT 859 897 HEAT 4.
REPEAT 901 938 HEAT 5.
REPEAT 942 979 HEAT 6.
REGION 325 375 Ran-GTP binding (By similarity).
MOD_RES 2 2 N-acetylalanine.
MOD_RES 827 827 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Repeat; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1097 AA |
Protein Sequence | MAAVLLRRLL SSAFDEVYPA LPSDVQTAIK SELLMIIQME TQSSMRKKVC DIAAELARNL 60
IDEDGNNQWP EGLKFLFDSV SSQNVGLREA ALHIFWNFPG IFGNQQQHYL DVIKRMLVQC 120
MQDQEHPSIR TLSARATAAF ILANEHNVAL FKHFADLLPG FLQAVNDSCY QNDDSVLKSL 180
VEIADTVPKY LRPHLEATLQ LSLKLCGDTS LNNMQRQLAL EVIVTLSETA AAMLRKHTNI 240
VAQTIPQMLA MMVDLEEDED WANADELEDD DFDSNAVAGE SALDRMACGL GGKLVLPMIK 300
EHIMQMLQNP DWKYRHAGLM ALSAIGEGCH QQMEGILNEI VNFVLLFLQD PHPRVRYAAC 360
NAVGQMATDF APGFQKKFHE KVIAALLQTM EDQGNQRVQA HAAAALINFT EDCPKSLLIP 420
YLDNLVKHLH SIMVLKLQEL IQKGTKLVLE QVVTSIASVA DTAEEKFVPY YDLFMPSLKH 480
IVENAVQKEL RLLRGKTIEC ISLIGLAVGK EKFMQDASDV MQLLLKTQTD FNDMEDDDPQ 540
ISYMISAWAR MCKILGKEFQ QYLPVVMGPL MKTASIKPEV ALLDTQDMEN MSDDDGWEFV 600
NLGDQQSFGI KTAGLEEKST ACQMLVCYAK ELKEGFVEYT EQVVKLMVPL LKFYFHDGVR 660
VAAAESMPLL LECARVRGPE YLTQMWHFMC DALIKAIGTE PDSDVLSEIM HSFAKCIEVM 720
GDGCLNNEHF EELGGILKAK LEEHFKNQEL RQVKRQDEDY DEQVEESLQD EDDNDVYILT 780
KVSDILHSIF SSYKEKVLPW FEQLLPLIVN LICPHRPWPD RQWGLCIFDD VIEHCSPASF 840
KYAEYFLRPM LQYVCDNSPE VRQAAAYGLG VMAQYGGDNY RPFCTEALPL LVRVIQSADS 900
KTKENVNATE NCISAVGKIM KFKPDCVNVE EVLPHWLSWL PLHEDKEEAV QTFNYLCDLI 960
ESNHPIVLGP NNTNLPKIFS IIAEGEMHEA IKHEDPCAKR LANVVRQVQT SGGLWTECIA 1020
QLSPEQQAAI QELLNSA 1037 |
Gene Ontology | GO:0005737; C:cytoplasm; TAS:ProtInc. GO:0005643; C:nuclear pore; TAS:ProtInc. GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. GO:0005095; F:GTPase inhibitor activity; TAS:ProtInc. GO:0008565; F:protein transporter activity; ISS:UniProtKB. GO:0008536; F:Ran GTPase binding; TAS:ProtInc. GO:0006607; P:NLS-bearing substrate import into nucleus; ISS:UniProtKB. GO:0006610; P:ribosomal protein import into nucleus; IDA:UniProtKB. GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. |
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